Pharmacological inhibition of protein aggregation within liquid condensates

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• Michele Vendruscolo (University of Cambridge)
• Monday 09 October 2023, 14:30-15:10
• Seminar Room 1, Newton Institute.

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SPLW03 - Biological condensates: cellular mechanisms governed by phase transitions

Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative diseases. Emerging evidence suggests that protein aggregation may occur within liquid condensates formed through phase separation. This mechanism of aggregation creates new challenges and opportunities for drug discovery for protein misfolding diseases, which are otherwise still largely incurable. I will discuss the possibility of inhibiting the process of condensation-driven aggregation using small molecules. By using a chemical kinetics approach, I will illustrate an example of a compound that inhibits the primary nucleation step in protein aggregation within condensates. These initial results suggest a possible therapeutic route for several neurodegenerative disorders.

This talk is part of the Isaac Newton Institute Seminar Series series.

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