Active biomolecular condensates on membranes

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• Christoph Weber (Universität Augsburg)
• Monday 09 October 2023, 11:50-12:30
• Seminar Room 1, Newton Institute.

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SPLW03 - Biological condensates: cellular mechanisms governed by phase transitions

The physics of biomolecular condensates provides a plethora of functionalities to living cells, including fluctuation buffering, selection and regulation of chemical reactions, and switch-like transitions of the condensate composition. In the presence of membrane surfaces, biomolecular condensates exhibit an even richer functionality by exploiting surface phase transitions, including wetting, prewetting, and surface phase separation. In contrast to the wetting of water drops on plant leaves, cellular surfaces are membranes with rich physico-chemical properties that include the active binding of condensate molecules into the membrane. Using theory, we show that active membrane binding and the physics of phase separation significantly alter the kinetics of wetting, leading to non-equilibrium steady states with condensate shapes reminiscent of a fried egg or a mushroom. 

This talk is part of the Isaac Newton Institute Seminar Series series.

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