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Fokker-Planck-based Inverse Reinforcement Learning --- A Physics-Constrained Approach to Markov Decision Process Models of Cell Dynamics

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USMW02 - Mathematical mechanical biology: old school and new school, methods and applications

Inverse Reinforcement Learning (IRL) is a compelling technique for revealing the rationale underlying the behavior of autonomous agents.  IRL seeks to estimate the unknown reward function of a Markov decision process (MDP) from observed agent trajectories. However, IRL needs a transition function, and most algorithms assume it is known or can be estimated in advance from data. It therefore becomes even more challenging when such transition dynamics is not known a-priori, since it enters the estimation of the policy in addition to determining the system’s evolution. When the dynamics of these agents in the state-action space is described by stochastic differential equations (SDE) in It\^{o} calculus, these transitions can be inferred from the mean-field theory described by the Fokker-Planck (FP) equation. We conjecture there exists an isomorphism between the time-discrete FP and MDP that extends beyond the minimization of free energy (in FP) and maximization of the reward (in MDP ). We identify specific manifestations of this isomorphism and use them to create a novel physics-aware IRL algorithm, FP-IRL, which can simultaneously infer the transition and reward functions using only observed trajectories.  We employ variational system identification to infer the potential function in FP, which consequently allows the evaluation of reward, transition, and policy by leveraging the conjecture. We demonstrate the effectiveness of FP-IRL by applying it to a synthetic benchmark and a biological problem of cancer cell dynamics, where the transition function is inaccessible. This is joint work with Changyang Huang, Siddhartha Srivastava, Kenneth Ho, Kathryn Luker, Gary Luker and Xun Huan.

This talk is part of the Isaac Newton Institute Seminar Series series.

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