University of Cambridge > > Darwin College Science Seminars > The awakening of the genome –modelling embryonic genome activation programs in vitro

The awakening of the genome –modelling embryonic genome activation programs in vitro

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If you have a question about this talk, please contact Dr Sandra Petrus-Reurer.

Grab some lunch from the Darwin servery and enjoy an interesting science talk and discussion over lunch (talk starts 13.10, so make sure you're seated by then). Looking forward to seeing you there.

The activation of the zygotic genome (ZGA) marks the first major wave of transcription in the developing embryo and is crucial for developmental progression. To identify the molecular details of this process, we use stem cells to model ZGA in vitro. Using novel single cell sequencing technologies in naïve embryonic stem cells, we identified human 8-cell like cells (8CLCs), that resemble the human 8-cell embryo at the time of zygotic genome activation. 8CLCs represent a unique novel model system to study processes regulating human ZGA in vitro and will provide critical insights into early events in human embryogenesis in vivo.

This talk is part of the Darwin College Science Seminars series.

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