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CATEGORIES:Darwin College Science Seminars
SUMMARY:The awakening of the genome –modelling embryonic g
 enome activation programs in vitro - Jasmin Tauben
 schmid-Stowers
DTSTART;TZID=Europe/London:20221110T131000
DTEND;TZID=Europe/London:20221110T140000
UID:TALK174527AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/174527
DESCRIPTION:The activation of the zygotic genome (ZGA) marks t
 he first major wave of transcription in the develo
 ping embryo and is crucial for developmental progr
 ession. To identify the molecular details of this 
 process\, we use stem cells to model ZGA in vitro.
  Using novel single cell sequencing technologies i
 n naïve embryonic stem cells\, we identified human
  8-cell like cells (8CLCs)\, that resemble the hum
 an 8-cell embryo at the time of zygotic genome act
 ivation. 8CLCs represent a unique novel model syst
 em to study processes regulating human ZGA in vitr
 o and will provide critical insights into early ev
 ents in human embryogenesis in vivo.
LOCATION:1 Newnham Terrace\, Darwin College
CONTACT:Dr Sandra Petrus-Reurer
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