Modelling bet-hedging: A link between cancer and the emergence of multicellularity

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• Frank Ernesto Alvarez Borges (Université Paris-Dauphine)
• Tuesday 03 May 2022, 14:50-15:35
• Seminar Room 2, Newton Institute.

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FKT - Frontiers in kinetic theory: connecting microscopic to macroscopic scales - KineCon 2022

Confronted with the biological problem of managing plasticity in cell populations, which is in particular responsible for transient and reversible drug resistance in cancer, we propose a rationale consisting of an integro-differential and a reaction-advection-diffusion equation, the properties of which are studied theoretically and numerically. By using a constructive finite volume method, we show the existence and uniqueness of a weak solution and illustrate by numerical approximations and their simulations the capacity of the model to exhibit divergence of traits. This feature may be theoretically interpreted as describing a physiological step towards multicellularity in animal evolution and, closer to present-day clinical challenges in oncology, as a possible representation of bet hedging in cancer cell populations.

This talk is part of the Isaac Newton Institute Seminar Series series.

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