Hydrodynamic simulation of multicellular embryo invagination and its biological predictions

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• Philippe-Alexandre Pouille, Institut Curie, Paris
• Wednesday 11 February 2009, 11:30-12:00
• Small Lecture Room, Microsoft Research, Roger Needham Building, 7 J J Thomson Avenue, Cambridge CB3 0FB.

If you have a question about this talk, please contact Dr Fabien Petitcolas.

Abstract: Classical simulations of morphogenesis model the embryo as a continuous medium, with visco-elastic behaviour, and use the finite element method to solve the dynamics. I will present you an original modelling of ventral invagination process during Drosophila gastrulation. It describes the structure of the embryo – membranes and cytosqueleton shaping cells and epithelium –enclosing a viscous fluid. The simulations reproduces in subcellular details the morphologic changes of the whole process and points out a unique biological activity that is sufficient to generate complete invagination.

Biography: Philippe-Alexandre Pouille is ending its thesis at Curie Institute in Paris, under the supervision of Emmanuel Farge. He obtained a master degree in Theoretical Physics of Complex Matter at the University of Paris Denis Diderot and has been awarded a Microsoft Research European PhD Scholarship.

This talk is part of the Dr Fabien Petitcolas's list series.

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