University of Cambridge > Talks.cam > Isaac Newton Institute Seminar Series > Session 2 - PLENARY TALK by Ruth Bowness - University of St. Andrews - Modelling within-host tuberculosis infection using a hybrid multiscale individual-based model

Session 2 - PLENARY TALK by Ruth Bowness - University of St. Andrews - Modelling within-host tuberculosis infection using a hybrid multiscale individual-based model

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IDPW04 - Within-Host Modelling

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Despite significant recent advances, TB is the biggest infectious killer globally – someone dies from the disease every 18 seconds. I will describe a hybrid multiscale individual-based model that has been developed to study disease progression and treatment in the human lung. The model contains discrete agents which model the spatio-temporal interactions (migration, binding, killing etc.) of bacteria and immune cells. Chemokine and oxygen dynamics are also included, as well as Pharmacokinetic/Pharmacodynamic models, which are incorporated into the model via PDEs. In this work, I explore concepts of relapse and latent TB disease, and their effect on treatment outcome.




This talk is part of the Isaac Newton Institute Seminar Series series.

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