Morphogenesis is stressful - The challenges of measuring tension in a 3D dynamic cell sheet

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• Stephanie Höhn (University of Cambridge)
• Thursday 07 February 2019, 13:00-14:00
• MR11, Centre for Mathematical Sciences, Wilberforce Road, Cambridge.

If you have a question about this talk, please contact Anne Herrmann.

Living tissues are intelligent materials that can change their mechanical properties while they develop. In spite of extensive studies in multiple model organisms we are only just beginning to understand these dynamic properties and their role in tissue development. Although many tissues are known to exhibit visco-elastic properties, it is unclear which properties dominate three-dimensional shape changes of cellular monolayers, such as epithelia. The inversion process in Volvox serves as model system for morphogenetic shape changes of cell sheets. During inversion an initially spherical cell sheet gradually adopts a mushroom shape through inwards folding (invagination) at the equator and contraction of the posterior hemisphere. Laser ablation is used to cut the cell sheet in order to determine the elastic properties in different regions and at different stages of inversion.

This talk is part of the DAMTP BioLunch series.

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