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Exploring the role of ion channels in cancer using executable modelling

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Ion channels play a major role in a wide range of biological processes, but their role in either cancer development or as an avenue for anti-cancer therapeutics is unclear. Dr Hall will show that based on TCGA expression data that ion channels are broadly dysregulated in cancer, and present a network model of channel co-regulation in osmostasis. This model can predict the known phenotypes of lymph node fibroblast reticular cells and mouse embryonic fibroblasts with heterozygous and homozygous Kras mutations. The model is further capable of predicting the response of these cells to protein knockouts by siRNA and in response to drug combinations, and these predictions are validated experimentally.

This talk is part of the Seminars on Quantitative Biology @ CRUK Cambridge Institute series.

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