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Cambridge Oncology Seminar Series
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This Seminar series covers clinical, laboratory and translational aspects of cancer. It is organised by members of the Cancer Research UK Cambridge Institute (CRUK CI), Clinical, Medical and Surgical Oncology and the Hutchison/MRC Research Centre. The programme is varied: in addition to external speakers, group leaders from each of the Departments give presentations. The talks are open to anyone from the University of Cambridge, Cancer Research UK and Addenbrooke’s Hospital. All talks take place on Tuesdays at 12 noon, unless otherwise indicated. The talks on the first Tuesday of the month are organised by the Hutchison/MRC Research Centre and take place in the Sackler Lecture Theatre, Level 7, CIMR . For information about this seminar series, please contact Anasuya Chattopadhyay (ac288@mrc-cu.cam.ac.uk) OR Judith Nial (jln23@mrc-cu.cam.ac.uk). The talks on the second, third and fourth Tuesdays of the month are held in the Cancer Research UK Cambridge Research Institute Lecture Theatre and the Sackler Lecture Theatre. These seminars are organised by Mala Jayasundera (mj319@cam.ac.uk). Members of the local pharma and biotechnology companies are also welcome to attend these seminars by prior arrangement with Neil Bennett (neil.bennett@cruk.cam.ac.uk). If you have a question about this list, please contact: Mala Jayasundera; Dr Ann Kaminski; Neil Bennett. If you have a question about a specific talk, click on that talk to find its organiser. 0 upcoming talks and 271 talks in the archive. CANCELLED - “Cancer genomics: from chromatin structure to new therapeutic targets”Host: Sakari Vanharanta Professor Elisa Oricchio (EPFL, Zurich). Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 April 2020, 11:30-12:30 ‘Cell Plasticity in Colon Carcinogenesis’Host: Grad Student Society - Professor Dr Florian Greten, Institute for Tumor Biology and Experimental Therapy, Frakfurt. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 December 2019, 11:30-12:30 ‘Activation of transcription factor Nrf2 as a strategy to restore the cellular redox and protein homeostasis’Host: Christian Frezza (CF366@hutchison-mrc.cam.ac.uk) Professor Albena Dinkova-Kostova,Jacqui Wood Cancer Centre, Division of Cellular Medicine, University of Dundee . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 01 October 2019, 11:30-12:30 ‘Treatment of cancer by inhibition of mtDNA gene expression’Host: Christian Frezza - (Hutchison/MRC Research Centre Seminar) Nils-Göran Larsson, MD, PhD, Professor, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Stockholm . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 September 2019, 11:30-12:30 ‘Combining omics data and biological knowledge to understand and treat cancer’Host: Christian Frezza Julio Saez-Rodriguez, Heidelberg University, Faculty of Medicine & EMBL- Heidelberg University Molecular Medicine Partnership Unit. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Wednesday 10 July 2019, 11:30-12:30 ‘Combining omics data and biological knowledge to understand and treat cancer’Host: Christian Frezza Julio Saez-Rodriguez, Institute for Tumor Biology and Experimental Therapy Frankfurt. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Monday 01 July 2019, 11:30-12:30 ‘Why Standard Naming and Pixel-based Contouring/Voluming are important to research in the radiation Oncology area’Host: Dr Richard Benson (richard.benson@addenbrookes.nhs.uk) Prof Andrew Miller, Radiation Oncologist, Illawarra Cancer Care Centre, Wollongong, NSW Australia / Adjunct Professor of Informatics, School of Informatics, University of Wollongong . Clinical School - Seminar room 10. Tuesday 11 June 2019, 12:00-13:00 ‘Next-Generation Biopsies in Gastrointestinal Cancers’Host: Dr Rebecca Fitzgerald (cf208@mrc-cu.cam.ac.uk) Dr Nicola Valeri, Institute of Cancer Research and The Royal Marsden NHS Trust. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 11 June 2019, 11:30-12:30 ‘New protagonists of the tumour microenvironment’Host: Sujath Abbas - sa837@mrc-cu.cam.ac.uk (Grad Student Society) Dr Ilaria Malanchi, Tumour-Host Interaction Lab,Francis Crick Institute, London . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 May 2019, 11:30-12:30 ‘Mammary epithelial cell fate and tumour initiation at the single cell resolution’Host: Rebecca Fitzgerald Walid Khaled, Department of Pharmacology, University of Cambridge. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 09 April 2019, 11:30-12:30 ‘Multi-dimensional cancer-immune cell interaction during metastasis’Host: Sakari Vanharanta (SV358@MRC-CU.cam.ac.uk) Xiang Zhang, Baylor College of Medicine, Houston, USA. Clifford Albutt Lecture theatre, Clinical School. Wednesday 27 February 2019, 12:00-13:00 THIS SEMIAR IS NOW CANCELLED - 'Cell Plasticity in Colon Carcinogenesis'Host: Graduate Student Society (Sujath Abbas) Professor Florian Greten, Institute for Tumor Biology and Experimental Therapy, Frankfurt. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 15 January 2019, 11:30-12:30 ‘Executable Disease Networks: Reconstruction, Topology, Dynamics’Host: Ben Hall Anna Niarakis, Université Paris-Saclay, Evry, France. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 04 December 2018, 11:30-12:30 ‘Nuclear Mechanopathology & Early Cancer Diagnostics’Host: Ashok Venkitaraman ((Hutchison/MRC Research Centre Seminar) Contact:pa-venkitaraman@mrc-cu.cam.ac.uk Professor GS Shivashankar, Deputy Director, Mechanobiology Institute, National University of Singapore. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Friday 15 June 2018, 10:30-11:30 ‘Cellular Plasticity in Cancer: driving force and therapeutic target’Host: Sakari Vanharanta (SV358@MRC-CU.cam.ac.uk) Hutchison/MRC Seminar Professor Thomas Brabletz, Department of Experimental Medicine, University Erlangen-Nuernberg. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 05 June 2018, 11:00-12:00 ‘Accelerating the translation of mutational signatures'Host: Professor Ashok Venkitaraman (Hutchison/MRC Research Centre Seminar) Contact:pa-venkitaraman@mrc-cu.cam.ac.uk Dr Serena Nik-Zainal, Wellcome Sanger Institute. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Thursday 03 May 2018, 11:00-12:00 "Proton Beam Therapy: Current and Future Provision"Host: Dr Gail Horan Yen-Ching Chang, Consultant in Clinical Oncology, UCHL. Cambridge Instute Lecture Theatre(CRUK) RobinsonWay Cambridge CB2 0RE. Tuesday 20 March 2018, 12:00-13:00 ‘Instituting Molecular Precision in Localised Prostate Cancer - A Cure for All?’Host: Professor Ashok Venkitaraman Rob Bristow, University Professor of Cancer Studies, Director of MCRC. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 06 March 2018, 11:30-12:30 Oxidative Stress Defences in CancerHost: Prof Ashok Venkitaraman (Queries to: AC288@MRC-CU.cam.ac.uk) Professor Joan Brugge, Louise Foote Pfeiffer Professor of Cell Biology and Director of the Ludwig Centre at Harvard University. Clifford Albutt Lecture theatre, Clinical School. Tuesday 06 February 2018, 14:30-15:30 ‘Tracking metabolic reprogramming in cancers with PI3K/Akt activation’Host: Christian Frezza George Poulogiannis, Team Leader, Division of Cancer Biology, Institute of Cancer Research, London. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 05 December 2017, 11:30-12:30 Metastasis latency: new molecular insightsHost: Sakari Vanharanta Roger Gomis, ICREA Research Professor, IRB Barcelona. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 November 2017, 11:30-12:30 ‘The role of Mre11 in DNA double strand break repair - myth and facts’Host: Ashok Venkitaraman Professor Shunichi Takeda, Department of Radiation Genetics, Kyoto University. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Monday 18 September 2017, 14:00-15:00 Satellite RNAs, Heterochromatin and Cancer: A Novel Mechanism of Induction of Breast Cancer by Loss of BRCA1?Host: Professor Ashok Venkitaraman Professor Inder Verma, Salk Institute, San Diego, USA . Clifford Albutt Lecture theatre, Clinical School. Monday 26 June 2017, 15:00-16:00 ‘Exploring and exploiting aberrant self-fate programs in leukemia’Host: Sakari Vanharanta (Hutchison/MRC talk) Dr Johannes Zuber, Research Institute of Molecular Pathology (IMP), Vienna, Austria. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 06 June 2017, 11:30-12:30 'Analyses for Rule-Based Models of Cellular Signalling'SPECIAL COMPUTATIONAL BIOLOGY SEMINAR - Host by: Dr Ben Hall Dr Jean Yang, Assistant Professor,Department of Computer Science, Carnegie Mellon University, Pittsburgh USA . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Thursday 25 May 2017, 15:00-16:00 ‘Alterations of the Polycomb machinery in cancers’Host: Sakari Vanharanta (Hutchison/MRC talk) Raphaël Margueron, Curie Institute, Paris. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 02 May 2017, 11:30-12:30 ‘Non-coding RNA - new roles for old players’Host: Dr Carla Martins Professor Anders Lund, Biotech Research and Innovation Centre, University of Copenhagen. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 March 2017, 11:30-12:30 The interaction between tumor hypoxia and DNA methylationHost: Professor Ashok Venkitaraman Dr Bernard Thienpont, VIB-KU Leuven Center for Cancer Biology, KU Leuven, Belgium. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 February 2017, 11:30-12:30 CANCELLED - Impact of the Microbiome on cancer and its treatmentHost: Dr Pippa Corrie Dr Trevor Lawley, Group Leader, Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute. Tuesday 29 November 2016, 12:00-13:00 "Mechanisms of colon cancer initiation, progression and metastasis"Host: Sakari Vanharanta (Hutchison/MRC talk) Joerg Huelsken, Associate Professor, Debiopharm Chair in Signal Transduction in Oncogenesis, EPFL, Lausanne. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 05 July 2016, 11:30-12:30 Mechanisms of lymphomagenesis: Developmental origins of a paediatric cancerHost Dr Simon Pacey Dr Suzanne Turner, Department of Pathology. Tuesday 28 June 2016, 12:00-13:00 Computational Radiotherapy Symposium, 2016: personalised radiotherapy, or how computers can cure cancerOrganiser: Prof Neil Burnet (jms203@medschl.cam.ac.uk Tel: 01223768433) Speakers as detailed in Symposium Programme. Thursday 09 June 2016, 12:30-17:30 Future of medicines development: capabilities and how industry is evolving and interacting with academia and the NHSHost: Dr Jean Abraham Andrew Hughes, Professor of Experimental Cancer Medicine,The Christie NHS Foundation Trust, Manchester. Tuesday 17 May 2016, 12:00-13:00 “Mechanisms of MYC-driven genome instability”Host: Dr Anna Philpott Jean Gautier, Professor of Genetic and Development, Institute for Cancer Genetics, Columbia University, New York (USA). Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 May 2016, 11:30-12:30 “Why Determining Pathogenicity in the Age of Precision Medicine, will Require More than Analyzing Genomic Sequences”Host: Dr Marc Tischkowitz Dr Bruce Gottlieb, Lady Davis Institute for Medical Research, Segal Cancer Centre, Jewish General Hospital, Department of Human Genetics, Department of Medicine, McGill University, Montreal, Canada. Tuesday 15 March 2016, 12:00-13:00 “New Developments in Molecular Imaging of Prostate Cancer”Host: Professor Fiona Gilbert Professor Wim Oyen, Professor of Nuclear Medicine and Molecular Imaging, ICR, London. Berridge Room, Department of Radiology, Level 5. Wednesday 09 March 2016, 17:00-18:00 Innate Genetics and the Tumour Microenvironment Cooperate to Drive Prostate Cancer AggressionHost: Dr Simon Pacey Prof Robert G Bristow, Senior Scientist, Princess Margaret Cancer Centre, Toronto. Tuesday 23 February 2016, 12:00-13:00 ‘Combine and conquer: critical pre-clinical and clinical aspects of targeted anti-cancer drugs’Host: Dr Simon Pacey Dr Udai Banerji, Drug Development Unit, ICR. Tuesday 08 December 2015, 12:00-13:00 "Tumor-induced reprogramming of hepatic metabolism disrupts anti‐tumor immunity”Host: Dr Simon Pacey Dr Tobias Janowitz, Department of Oncology. Tuesday 24 November 2015, 12:00-13:00 Intrinsic and extrinsic determinants of pancreatic cancer stem cellsHost: Hutchison/MRC Research Centre Graduate Student Society Professor Christopher Heeschen, Centre Lead, Centre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, London. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 17 November 2015, 11:30-12:30 Melanoma and the translational cycle of innovation in cancer therapeuticsHost: Dr Pippa Corrie Professor Grant McArthur, Peter MacCallum Cancer Centre, Victoria, Australia. Tuesday 13 October 2015, 12:00-13:00 Genomics of radiation responses and radiosensitivityHost: Dr Ajithkumar Professor Michael McKay, North Coast Cancer Institute, NSW, Australia. Tuesday 15 September 2015, 12:00-13:00 CANCELLED - "Synergistic effect of radiotherapy and cis-platinum chemotherapy delivered via gold nanoparticles in glioblastoma multiforme"CANCELLED Dr Sara Piccirillo, Department of Clinical Neurosciences and Alexandra Vaideanu, Deptatment of Engineering . Tuesday 08 September 2015, 12:00-13:00 ‘Novel dual-action combination therapy enhances angiogenesis whilst reducing tumour growth and spread’Hosts: Jacqui Shields/Sakari Vanharanta (Hutchison/MRC Research Centre) Professor Kairbaan Hodivala-Dilke, Professor of Angiogenesis, Deputy Institute Director QMUL . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 July 2015, 11:00-12:00 Interrogating the Architecture of Cancer GenomesHost : Dr Bristi Basu Dr Peter Campbell, Head of Cancer Genome Project, Wellcome Trust Sanger Institute.. Tuesday 23 June 2015, 12:00-13:00 'Harnessing hypoxia signalling in cancer'Host: Dr Simon Pacey Professor Margaret Ashcroft, Cambridge Cardiovascular. Tuesday 09 June 2015, 12:00-13:00 'ECM remodelling during cancer progression'Hosts: Sakari Vanharanta and Jacqui Shields (Hutch) Dr Janine Erler, Associate Professor - Biotech Research & Innovation Centre (BRIC),Copenhagen . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 02 June 2015, 12:00-13:00 DNA damage response: Mechanisms and relevance for cancer development and treatmentHutchison/MRC Research Centre Seminar - Host: Hutchison/MRC Research Centre Graduate Student Society Professor Jiri Bartek, The Danish Cancer Society Research Center Genome Integrity Unit, Denmark. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 19 May 2015, 12:00-13:00 "Designing trials to find the right dose"Host: Dr Simon Pacey Dr Adrian Mander - Director of MRC Biostatistics Unit Hub for Trials Methodology Research, Cambridge. Tuesday 12 May 2015, 12:00-13:00 Metastatic Stem Cells, TGF-beta signalling and poor-prognosis in CRCHutchison/MRC Research Centre Seminar Dr Eduard Batlle (Group Leader, Institute for Research in Biomedicine, Barcelona). Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 05 May 2015, 12:00-13:00 Defining treatment paradigms in prostate cancer; the UK as a dominant force - past, present, and futureHost: Dr Simon Pacey Professor Malcolm Mason, NCRI Prostate Cancer Clinical Studies Group and School of Medicine, Cardiff University. Tuesday 14 April 2015, 12:00-13:00 Systems Biology of CancerHost: Hutchison/MRC Research Centre Graduate Student Society Professor Jussi Taipale, Department of Biosciences and Nutrition, Karolinska Institute, Sweden . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 March 2015, 12:00-13:00 MYC Oncoproteins act as Epigenetic ModifiersHutchison/MRC Research Centre Seminar - Host by: Dr Anna Philpott Dr Frank Westermann, Research Group Neuroblastoma Genomics, DKFZ, Heidelberg. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 February 2015, 12:00-13:00 “Optimizing Image Guided Radiotherapy for Patient Benefit”Host: Professor Neil Burnet Dr Peter Remeijer, Medical Physicist NKI /Avl, Amsterdam. Tuesday 27 January 2015, 12:00-13:00 Explaining the reduction in ovarian cancer mortality 1977 to 2014Host: Dr Marc Tischkowitz Dr Steven Narod, Director, Familial Breast Cancer Research Unit, Women's College Research Institute, Toronto, Canada. Tuesday 13 January 2015, 12:00-13:00 Ovarian Cancer in TransitionHost: Dr Christine Parkinson Mr Douglas Levine, Gynecology Service, Department of Surgery. Tuesday 16 December 2014, 12:00-13:00 In vivo function-based genomic approaches for cancer drug target discoveryHutchison/MRC Research Centre Seminar Professor Daniel Peeper, Head, Division of Molecular Oncology, The Netherlands Cancer Institute. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 02 December 2014, 12:00-13:00 Cell fate in response to anti-mitotic chemotherapeuticsHutchison/MRC Research Centre Seminar (please note unusual date) Professor Stephen Taylor, Faculty of Life Sciences, University of Manchester. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Wednesday 19 November 2014, 12:00-13:00 Tracking genomic aberrations of the androgen receptor (AR) in castration-resistant prostate cancer (CRPC)Host: Dr Simon Pacey Dr Gerhardt Attard, Royal Marsden Hospital, London. Tuesday 18 November 2014, 12:00-13:00 “Stratified Medicine in Cancer Therapy - a practical guide”Host: Dr Nitzan Rosenfeld Professor Gary Middleton, Professor in Medical Oncology, School of Cancer Sciences, University of Birmingham. Tuesday 11 November 2014, 12:00-13:00 "The role of epigenetic regulators and their therapeutic targeting in Acute Myeloid Leukaemia and haematological malignancies”Host: Professor Duncan Jodrell Dr Brian Huntly, Department of Haematology, Cambridge University. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 21 October 2014, 12:00-13:00 CANCELLED - Lung cancer, biomarkers and unanswered questions - a clinical translational perspectiveHost: Dr Simon Pacey Dr Fiona Blackhall, Consultant Medical Oncologist, The Christie Hospital, Manchester . CRI Lecture Theatre, Cambridge Research Institute. Tuesday 14 October 2014, 12:00-13:00 The role of stem cells in the pathogenesis of hepato-biliary cancersHutchison/MRC Research Centre Seminar Professor Nisar Malek, University of Tubingen, Germany. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 October 2014, 12:00-13:00 “CDD’s new Research Strategy”Host: Professor Duncan Jodrell Dr Nigel Blackburn, Director of Centre for Drug Development, Cancer Research UK. Tuesday 07 October 2014, 12:00-13:00 “Paradigm changes produced by targeted agents in Phase I trials in Oncology. Case studies of a TFbeta inhibitor and a Sonic Hedgehog inhibitor”Host: Dr Richard Baird Dr Jordi Rodon, Head of Research Unit for Molecular Therapy of Cancer Oncology Department. Vall D’Hebron University Hospital, Barcelona, Spain. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 09 September 2014, 12:00-13:00 Cellular hierarchies in normal and malignant epithelial tissueCRUK CI open seminar John Stingl, Cancer Research UK Cambridge Institute. Cancer Research UK Cambridge Institute, Lecture Theatre. Monday 28 July 2014, 14:45-15:45 'Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC): a springboard for renal cancer biomarker development’.Host: Professor Tim Eisen Mr Grant Stewart, Clinical Senior Lecturer and Honorary Consultant in Urological Surgery, University of Edinburgh . CRI Lecture Theatre, Cambridge Research Institute. Tuesday 22 July 2014, 12:00-13:00 Noninvasive cancer genomicsCRUK CI seminar Nitzan Rosenfeld, Cancer Research UK Cambridge Institute. Friday 27 June 2014, 13:45-14:45 Precision Cancer Prevention: Trying to use Genomics to Save LivesHost: Dr Marc Tischkowitz John Hopper, Professor & Director (Research), Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, University of Melbourne, Australia. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 24 June 2014, 12:00-13:00 Breast Imaging research in CambridgeHost: Dr Richard Baird Professor Fiona Gilbert, Head of Department of Radiology, Cambridge. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 10 June 2014, 12:00-13:00 Undermining Myc: Mitochondria Hold the KeyHutchison/MRC Research Centre Seminar Dr Daniel Murphy, Institute of Cancer Sciences, University of Glasgow. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 June 2014, 12:00-13:00 Personalised Cancer Medicine. How do we get there?Host: Dr Jean Abraham Dr Helena Earl, Dept. of Oncology, University of Cambridge. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 20 May 2014, 12:00-13:00 "From trials evaluating drugs to trials evaluating treatment algorithms – Focus on the SHIVA trial"Host: Dr Gill Barnett Dr Christophe Le Tourneau, Medical Oncologist, Head of the Phase I Program at the Institut Curie, Paris, France,. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 13 May 2014, 12:00-13:00 Spatio-temporal control of RhoGTPases and the cytoskeleton in invading cancer cells by integrins and endocytic traffickingHutchison/MRC Research Centre Seminar Dr Patrick Caswell, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 06 May 2014, 12:00-13:00 Centrosome changes in cancer – causes and consequencesCRUK CI guest seminar Monica Bettencourt Dias, Instituto Gulbenkian de Ciência. Wednesday 09 April 2014, 11:00-12:00 Targeting bioenergetics in hypoxic and rapidly growing tumoursHutchison/MRC Research Centre Seminar Dr Jacques Pouysseggur, Institute of Research on Cancer and Ageing (IRCAN), Nice, France. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 08 April 2014, 12:00-13:00 “Personalized Medicine in Oncology: The Dutch experience”Host: Dr Richard Baird Professor Jaap Verweij, Erasmus MC Cancer Institute, Weytemaweg 80, 3105 CN Rotterdam, The Netherlands. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 01 April 2014, 12:00-13:00 Cell death and autophagy in response to inhibition of glycolysisHutchison/MRC Research Centre Seminar Dr Cristina Muñoz Pinedo, IDIBELL, Barcelona, Spain. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 04 March 2014, 12:00-13:00 “What can we do to accelerate the discovery of new medicines for patients?”Host: Dr Bristi Basu Professor Chas Bountra, Head of Structural Genomics Consortium, University of Oxford, Nuffield Dept of Clinical Medicine . CRI Lecture Theatre, Cambridge Research Institute. Tuesday 11 February 2014, 12:00-13:00 Translating Tumour Metabolism into New Diagnostics and Novel Anti-Cancer TherapeuticsHutchison/MRC Research Centre Seminar Professor Michael Lisanti, Director of the Breakthrough Breast Cancer Research Unit, University of Manchester. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 04 February 2014, 12:00-13:00 Personalized medicine initiative at Gustave RoussyHost: Dr Richard Baird Professor Jean-Charles SORIA - Chef de Service, Professor of Medicine and Medical Oncology, Paris University XI and cancer specialist at Institut Gustave, Roussy.. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 14 January 2014, 12:00-13:00 Chasing metabolic alterations in cancerHutchison/MRC Research Centre Seminar Dr Arkaitz Carracedo, CIC bioGUNE, (Center for Cooperative Research in Biosciences), Derio, Spain. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 January 2014, 12:00-13:00 CANCELLEDHost: Dr Richard Baird Prof Josep Tabernero, Head, Medical Oncology Department, Vall d' Hebron University Hospital, Barcelona, Spain. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 17 December 2013, 12:00-13:00 The autophagy signaling network in the coordination of a cell's responseHutchison/MRC Research Centre Seminar Prof Francesco Cecconi, University of Tor Vergata, Italy . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 December 2013, 12:00-13:00 "The Cambridge Breast Cancer Programme"Host: Dr Richard Baird Prof Carlos Caldas, CRUK Cambridge Research Institute. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 26 November 2013, 12:00-13:00 MRC Cancer Unit Annual Lecture The p53 pathway: 21 years of the "guardian of the genome"Refreshments will be available after this talk outside the lecture theatre Prof Sir David Lane, Chief Scientist, A*STAR, Singapore. Max Perutz Lecture Theatre, MRC Laboratory of Molecular Biology. Monday 04 November 2013, 16:00-17:30 CANCELLED - Scottish Collaboration On Translational Research into Renal Cell Cancer, developing a systems medicine approach to personalised treatmentMr Grant Stewart, Department of Urology and Edinburgh Urological Cancer Group,Western General Hospital. Edinburgh. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 29 October 2013, 12:00-13:00 Spotlight on Cambridge Clinical Trials; Presentations from the American Society of Oncology (ASCO) Annual Meeting 2013Host: Dr Simon Pacey Prof Tim Eisen, Dr Hugo Ford, Dr Pippa Corrie & Dr Kate Fife. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 08 October 2013, 12:00-13:00 Target-Based Approach in Early-Phase Clinical Trials in CancerHost: Dr Richard Baird Filip Janku, Investigational Cancer Therapeutics, (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center, Houston. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 01 October 2013, 12:00-13:00 CANCELLEDProfessor Charles Swanton, CRUK & UCL Trials Centre, UCL. Tuesday 24 September 2013, 12:00-13:00 Advances in non-surgical treatment for cervix cancerDr Li Tee Tan, Addenbrooke's . Tuesday 10 September 2013, 12:00-13:00 Insights for the role of tumour-related inflammation and stem cells in DrosophilaHutchison/MRC Research Centre Seminar Dr Marcos Vidal, Beatson Institute, Glasgow . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 September 2013, 12:00-13:00 Risk and uncertainty in radiotherapy. Why I am the weakest link?Dr Tom Roques, Lead of Head and Neck Cancer Multidisciplinary Team, Norfolk and Norwich Hospital. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 16 July 2013, 12:00-13:00 Genetic modifiers and microenvironmental control of tumor invasivenessHutchison/MRC Research Centre Seminar- Please note unusual time and 1:00pm start Prof Douglas Hanahan, EPFL, Switzerland . Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 02 July 2013, 13:00-14:00 "Image guidance – benefits and risks"Professor Marcel van Herk, Imaging Physicist, Project Leader, The Netherlands Cancer Institute. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 25 June 2013, 12:00-13:00 Economics of Cancer MedicinesProfessor Richard Sullivan, Guy's Hospital, London. Tuesday 11 June 2013, 12:00-13:00 Control of cytokinesis and the dark side of actomyosin forcesHutchison/MRC Research Centre Seminar Dr Mark Petronczki, London Research Institute. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 04 June 2013, 12:00-13:00 "Renal Cancer and Oxygen Sensing"Prof Patrick Maxwell, Regius Professor of Physic, University of Cambridge. Tuesday 28 May 2013, 12:00-13:00 ‘CLL – from chemotherapy to targeted kinase inhibition’Buffet Lunch will be provided by courtesy of Chugai Pharma UK Ltd. Dr George Follows, Consultant Haematologist, Addenbrooke's . Tuesday 14 May 2013, 12:00-13:00 Macrophages Into Tumor Hypoxic Areas: Should I Stay Or Should I Go?Hutchison/MRC Research Centre Seminar Dr Massimiliano Mazzone, VIB Vesalius Research Center, Belgium. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 May 2013, 12:00-13:00 “The identification of patients who benefit from targeted therapy in renal cancer”(The lunch will be provided by courtesy of Pfizer) Professor Thomas Powles, Barts Cancer Institute, Queen Mary University of London. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 23 April 2013, 12:00-13:00 CANCELLEDDr Fiona Blackhall, Manchester University, Manchester Cancer Research Centre Lung Group Lead. Tuesday 12 March 2013, 12:00-13:00 Challenges in Implementing Personalized Cancer Medicine: the IGR experienceProfessor Alexander Eggermont, Director General, Institut de Cancérologie Gustave Roussy, France. Tuesday 19 February 2013, 12:00-13:00 Telomeres and the challenges to chromosome integrityHutchison/MRC Research Centre Seminar Dr Julie Cooper, London Research Institute. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 05 February 2013, 12:00-13:00 Localisation-based feedback controls during mitosis and the maintenance of chromosomal stabilityHutchison/MRC Research Centre Seminar Dr Adrian Saurin, University Medical Center Utrecht, The Netherlands. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 04 December 2012, 12:00-13:00 Cellular responses to DNA damage: translating molecular insights towards new cancer therapiesProf Steve Jackson, Head of Cancer Research UK Laboratories The Gurdon Institute, Cambridge. Tuesday 27 November 2012, 12:00-13:00 Mechanisms of Estrogen Receptor Transcription in Breast CancerDr Jason Carroll, CRUK Cambridge Research Institute. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 20 November 2012, 12:00-13:00 "Towards personalized medicine in Breast Cancer"Prof. Dr. Sabine C. Linn, medical oncologist Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. Tuesday 13 November 2012, 12:00-13:00 A systems view of the cancer cell: from missing genetic variability to combination therapyAndrea Califano, Columbia University. Wednesday 07 November 2012, 10:30-11:30 A genomic Odyssey of predicting drug response: is Ulysses home yet?Dr Federico Innocenti, UNC Institute for Pharmacogenomics and Individualized Therapy. Tuesday 06 November 2012, 16:00-17:00 Signalling Networks in Cell Proliferation and Fate ControlHutchison/MRC Research Centre Seminar Professor Sibylle Mittnacht, UCL Cancer Institute. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 06 November 2012, 12:00-13:00 'Circulating Tumour Cells: Biomarker Utility and Insights to Metastasis'Professor Caroline Dive, Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester. Tuesday 14 August 2012, 12:00-13:00 Understanding Response & Resistance Mechanisms to Targeted TherapyNote unusual day and time Dr Keith Flaherty, Director of Developmental Therapeutics at Massachusetts General Hospital. Thursday 21 June 2012, 16:00-17:00 Cancer-related inflammationDr Thorsten Hagemann, Barts Cancer Institute, Queen Mary University of London. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 12 June 2012, 12:00-13:00 Pancreatic cancer: Genetic models to develop novel diagnostic and therapeutic strategiesDr Dieter Saur, The Technical University of Munich. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 29 May 2012, 12:00-13:00 "Strategies to enhance effectiveness of Radiotherapy in Pancreatic Cancer"Dr Thomas Brunner, Gray Institute for Radiation Oncology and Biology, Oxford. Tuesday 15 May 2012, 12:00-13:00 Investigating key effectors downstream of APC (adenomatous polyposis coli) deletion in vivoHutchison/MRC Research Centre Seminar Prof Owen Sansom, Beatson Institute, Glasgow. Max Perutz Lecture Theatre, MRC LMB. Tuesday 08 May 2012, 12:00-13:00 ALK Hunting in Colorado - new drugs for lung cancer's new diseasesNote unusual day and time Dr Ross Camidge, University of Colorado Hospital (UCH) and the University of Colorado Cancer Center,. Thursday 03 May 2012, 17:00-18:00 CANCELLEDProf Richard Sullivan, Professor, Kings College London, Director, Centre for Global OncoPolicy & Health Kings Health Partners. Tuesday 24 April 2012, 12:00-13:00 Always on guard: p53 dynamics in single living cellsHutchison/MRC Research Centre Seminar Dr Alexander Loewer, Berlin Institute for Medical Systems Biology, Max Delbrueck Center, Germany. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 03 April 2012, 12:00-13:00 "Exploiting ASS1 deficiency in the treatment of mesothelioma"Dr Peter Szlosarek, Cancer Research UK Clinician Scientist, Senior Lecturer and Honorary Consultant in Medical Oncology, Barts and The London. Seminar Room 2, Clinical School, Addenbrooke’s. Tuesday 27 March 2012, 11:30-13:00 "Thalidomide and its analogues ; How molecules selected for anti-TNFa activity affect so many different pathways with direct binding with Cereblon mediating both anti proliferative and Immunomodulatory functions"Individuals who are interested in meeting with any of the speakers should contact me asap. Thanks, Jonathan (jlh66@cam.ac.uk) Jerome B. Zeldis CEO of Celgene Global Health & Angus Dalgleish, St George's Hospital London. Tuesday 20 March 2012, 12:00-13:00 "Re Service Reforms in the new Commissioning Landscape"Hannah Farrar, Director of Strategy and System Management, NHS, London. CRI Lecture Theatre, Cambridge Research Institute. Tuesday 13 March 2012, 12:00-13:00 "DICER1 and miRNA processing - a novel paradigm in cancer predisposition"Dr Marc Tischkowitz, Dept of Medical Genetics, University of Cambridge. Tuesday 28 February 2012, 12:00-13:00 "Myeloproliferative neoplasms – JAK/STAT signalling and stem cell subversion"Prof Tony Green, University of Cambridge Department of Haematology. Tuesday 21 February 2012, 12:00-13:00 "Radiotherapy toxicity, Radiogenomics and RAPPER"Dr Gill Barnett, Dept. of Oncology. Tuesday 14 February 2012, 12:00-13:00 Transcriptional control of EMT and malignant tumor progressionHutchison/MRC Research Centre Seminar Prof Gerhard Christofori, University of Basel, Switzerland. Sackler Lecture Theatre (Level 7), Cambridge Institute for Medical Research. Tuesday 07 February 2012, 12:00-13:00 “Imaging Biomarkers in Cancer”Prof. Fiona Gilbert, Dept. of Radiology. Sackler Lecture Theater on level 7 of the CIMR (Cambridge Institute for Medical Research). Tuesday 24 January 2012, 12:00-13:00 Neo-adjuvant radiochemotherapy in breast cancerDr Alain Fourquet, Department of Radiation Oncology, Institut Curie, Paris. Tuesday 13 December 2011, 12:00-13:00 Integration of Cell Growth and Cell Metabolism by MycHutchison/MRC Research Centre Seminar Prof Martin Eilers, Theodor-Boveri-Institute, University of Würzburg, Germany. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 06 December 2011, 12:00-13:00 Cancer Gene Discovery in the MouseHutchison/MRC Research Centre Seminar Dr David Adams, Wellcome Trust Sanger Institute. Max Perutz Lecture Theatre, MRC LMB. Tuesday 01 November 2011, 12:00-13:00 ‘Genetic predisposition to cancer’Prof Bruce Ponder, Cancer Research UK Cambridge Research Institute. Tuesday 18 October 2011, 12:00-13:00 Tumour-stroma Interactions in Breast CancerHutchison/MRC Research Centre Seminar Prof Clare Isacke, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 04 October 2011, 12:00-13:00 DNA repair inhibitors in cancer treatmentProf Hilary Calvert, UCL Cancer Institute. Tuesday 20 September 2011, 12:00-13:00 Haploid Genetic Screens in Human CellsHutchison/MRC Research Centre Seminar Dr Thijn Brummelkamp, Netherlands Cancer Institute. Max Perutz Lecture Theatre, MRC LMB. Tuesday 06 September 2011, 12:00-13:00 The ATM-mediated DNA damage response: moving between the forest and the treesHutchison/MRC Research Centre Seminar Dr Yossi Shiloh, Tel Aviv University, Israel. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 28 June 2011, 12:00-13:00 ‘Viral and host contributions to cervical carcinogenesis’Dr Nick Coleman, Department of Pathology & Hutchison/MRC Research Centre. Tuesday 21 June 2011, 12:00-13:00 "Advances in Head and Neck Radiotherapy"Dr Chris Nutting, Royal Marsden Hospital. Tuesday 14 June 2011, 12:00-13:00 "Developing Medicines for Pancreatic Cancer"Dr Dave Tuveson, CRUK Cambridge Research Institute. Tuesday 07 June 2011, 12:00-13:00 SOCCAR trial: an updateDr Joe Maguire, Consultant Clinical Oncologist, Clatterbridge Centre for Oncology. Tuesday 31 May 2011, 12:00-13:00 “What lessons can we learn from transcriptional evolution in cancer research?”Dr Duncan Odom, CRUK Cambridge Research Institute. Tuesday 24 May 2011, 12:00-13:00 CANCELLEDProf. Roy Rampling, University of Glasgow and The Beatson Cancer Centre, Glasgow. Tuesday 17 May 2011, 12:00-13:00 "Multi-site post-translational modification as a quantitative regulator of transcriptional output during neurogenesis"Dr Anna Philpott, Department of Oncology, MRC-Hutchison Research Centre. Tuesday 10 May 2011, 12:00-13:00 CANCELLEDHutchison/MRC Research Centre Seminar Prof Sibylle Mittnacht, The Institute of Cancer Research. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 03 May 2011, 12:00-13:00 CANCELLEDDr Vincent Gnanapragasam, Hutchison/MRC Research Centre & Addenbrooke's Hospital. Tuesday 26 April 2011, 12:00-13:00 "Somatic Genetics of Human Cancer - Moving Towards Large Scale Resequencing of Cancer Genomes"Dr Andy Futreal, The Wellcome Trust Sanger Institute, Hinxton. Tuesday 12 April 2011, 12:00-13:00 "The Cambridge breast cancer program- recent progress"Dr Carlos Caldas, CRUK Cambridge Research Institute. Tuesday 15 March 2011, 12:00-13:00 "FGF-2, S6 Kinase 2 and Chemo-resistance in Lung Cancer"Prof. Michael Seckl, Imperial College, London and Charing Cross Hospital. Tuesday 08 March 2011, 12:00-13:00 Mesothelioma: a disease of our timeDr David Gilligan, Addenbrooke's Hospital. Tuesday 22 February 2011, 12:00-13:00 "Targetting pre-neoplasia in the bronchus"Dr Robert Rintoul, Papworth Hospital. Tuesday 15 February 2011, 12:00-13:00 Application of Systems Biology Approaches to Study Cell Signalling and TranscriptionHutchison/MRC Research Centre Seminar Prof Mike White, University of Liverpool. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 01 February 2011, 12:00-13:00 "Leukaemia stem cells: how normal stem cell function is subverted in haematological malignancies"Dr Brian Huntly, Department of Haematology. Tuesday 25 January 2011, 12:00-13:00 “Breast MRI by the Shutter-Speed Method: Elimination of Unnecessary Breast Biopsies"Dr Charles S. Springer, Jr., Advanced Imaging Research Centre. Oregon Health & Science University. Tuesday 21 December 2010, 12:00-13:00 RCC Cinderella comes of ageProf. Tim Eisen, Dept. of Oncology, University of Cambridge & Addenbrooke's Hospital. Tuesday 14 December 2010, 12:00-13:00 Neuroblastoma- Disordered Developmental Programs Contribute to TumorigenesisHutchison/MRC Research Centre Seminar- Please note change to regular time and date Prof Carol Thiele, National Cancer Institute, USA. Sackler Lecture Theatre, CIMR, Level 7. Thursday 02 December 2010, 14:30-15:30 "Susceptibility to Cancer - What's New?"Prof Doug Easton, Strangeways Research Laboratory. Tuesday 30 November 2010, 12:00-13:00 Targeting NG2 Cells in GlioblastomaDr Colin Watts, Cambridge Centre for Brain Repair. Tuesday 23 November 2010, 12:00-13:00 "Chromosome Translocations and Tumour Suppressors in Breast Cancer"Dr Paul Edwards, Hutchison/MRC Research Centre. Tuesday 26 October 2010, 12:00-13:00 "Brain Metastases – a cross cutting theme: Review of the Brain Metastasis Service and Future Research Potential"Dr Sarah Jefferies, Addenbrooke's Hospital. Tuesday 19 October 2010, 12:00-13:00 "Imaging Tumour Cell Death"Prof. Kevin Brindle, CRUK Cambridge Research Institute. Tuesday 12 October 2010, 12:00-13:00 “EGFR Mutation Screening in NSCLC”Dr David Gonzalez de Castro, The Institute of Cancer Research and Royal Marsden Hospital. Tuesday 28 September 2010, 12:00-13:00 Pathway Analysis of Glioblastoma Tissue After Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib – A Phase “0 Trial”Dr Monika Hegi, University Hospital (CHUV), Lausanne, Switzerland. Tuesday 21 September 2010, 12:00-13:00 Interactions of Epidermal Growth Factor Receptor Inhibition with DNA damage in the treatment of gastrointestinal cancerProf Daniel Hochhauser, University College London. Tuesday 14 September 2010, 12:00-13:00 Unravelling cancer cell signalling networks and screening for novel drug targetsHutchison/MRC Research Centre Seminar Daniel Peeper, The Netherlands Cancer Institute. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 07 September 2010, 12:00-13:00 "Breast Radiotherapy - Past, Present and Future"Dr Charlotte Coles, Addenbrooke's Hospital. Tuesday 29 June 2010, 12:00-13:00 "Gastro Intestinal Stroma Tumours (GISTS)"Dr Ramesh Bulusu, Addenbrooke's Hospital. Tuesday 22 June 2010, 12:00-13:00 Dynamic Notch signaling in neural progenitor cellsHutchison/MRC Research Centre Seminar Ryoichiro Kageyama, Kyoto University, Japan. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 15 June 2010, 12:00-13:00 "A New Window of Opportunity in Prostate Cancer"Dr Danish Mazhar, Addenbrooke's Hospital. Tuesday 25 May 2010, 12:00-13:00 "Stem cell identity and mRNA export: unexpected roles of geminin and GANP"Prof. Ron Laskey, Hutchison/MRC Research Centre. Tuesday 18 May 2010, 12:00-13:00 "Cellular Senescence as a Tumour Suppressor Mechanism, Particular Focus will be on the Autophagy/mTOR Pathway"Dr Masashi Narita, CRUK Cambridge Research Institute. Tuesday 11 May 2010, 12:00-13:00 Mechanisms regulating neural differentiationHutchison/MRC Research Centre Seminar Kate Storey, University of Dundee. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 04 May 2010, 12:00-13:00 “Macromolecular interactions in the control of chromosome instability”Prof. Ashok Venkitaramann, (Hutchison-MRC Research Centre). Tuesday 27 April 2010, 12:00-13:00 The NCAG Report: Delivering a World Class Chemotherapy ServiceProf Roger James, Previously: • Deputy Medical Director Maidstone and Tunbridge Wells NHS Trust • Medical Director Kent & Medway Cancer Network. Tuesday 20 April 2010, 12:00-13:00 "Non-Invasive Diagnosis of Brain Cancer"Prof. John Griffiths, CRUK Cambridge Research Institute. Tuesday 30 March 2010, 12:00-13:00 Deciphering the Mammary Epithelial Cell HierarchyDr John Stingl, CRUK Cambridge Research Institute. Tuesday 16 March 2010, 12:00-13:00 "The Fine Scale Mapping of Breast Cancer Loci found via GWAS - searching for the Causative Variants"Dr Alison Dunning, Strangeways Research Laboratory. Tuesday 09 March 2010, 12:00-13:00 The Role of the Receptor Tyrosine Kinase Antagonist, Lrig1, in Normal Tissue Homeostasis and CancerHutchison/MRC Research Centre Seminar Kim Jensen, Anne McLaren Laboratory for Regenerative Medicine and Department of Oncology. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 02 March 2010, 12:00-13:00 CANCELLEDDr Alison Dunning, Strangeways Research Laboratory & Dept. of Oncology. Tuesday 23 February 2010, 12:00-13:00 The prognostic significance of subtypes of breast cancer classified using immunohistochemistryDr Paul Pharoah, Strangeways Research Laboratory/Oncology. Tuesday 16 February 2010, 12:00-13:00 High-throughput Cancer Cell line Screens: Linking Drug Response to Molecular SignaturesDr Ultan McDermott, Cancer Genome Project, Wellcome Trust Sanger Institute. Tuesday 09 February 2010, 12:00-13:00 Can we age in utero? Can we kill cancer cells by making them replicate faster? And other ATR stories…Hutchison/MRC Research Centre Seminar Oscar Fernandez-Capetillo, Spanish National Cancer Research Centre (CNIO). Sackler Lecture Theatre, CIMR, Level 7. Tuesday 02 February 2010, 12:00-13:00 HPV vaccines - will they do their job?Prof. Margaret Stanley, Dept. of Pathology, University of Cambridge. Tuesday 26 January 2010, 12:00-13:00 Investigating the interaction of Radiotherapy & Temozolomidefor GlioblastomaDr Raj Jena, Addenbrooke's Hospital. Tuesday 19 January 2010, 12:00-13:00 PREDICT: A NEW UK PROGNOSTIC MODE THAT PREDICTS SURVIVAL FOLLOWING SURGERY FOR INVASIVE BREAST CANCER (GC Wishart, EM Azzato, PDP Pharoah, DC Greenberg, J Rashbass, O Kearins, G Lawrence, C Caldas C, PM Ravdin)Prof. Gordon Wishart, Addenbrooke's Hospital. Tuesday 12 January 2010, 12:00-13:00 The new LAW of microRNA-mediated gene silencing: implications for lung cancer developmentDr Tyson V. Sharp, School of Biomedical Sciences, University of Nottingham. Tuesday 15 December 2009, 12:00-13:00 Cellular senescence: molecular mechanisms and implications for cancer and agingHutchison/MRC Research Centre Seminar Peter Adams, Beatson Institute for Cancer Research, Glasgow. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 01 December 2009, 12:00-13:00 “Intensity modulated radiotherapy for children’s tumours and estimation of the carcinogenic risk”Dr Michael Williams & Dr Gail Horan, Addenbrooke's Hospital. Tuesday 24 November 2009, 12:00-13:00 "The Arguments for and against Sentinel Node Biopsy (SNB) in Melanoma"Prof. J Meirion Thomas, Royal Marsden Hospital & Imperial College, London. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 17 November 2009, 12:00-13:00 The irreversibility of cell cycle transitions: why the clock never turns backHutchison/MRC Research Centre Seminar Frank Uhlmann, CRUK London Research Institute. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 03 November 2009, 12:00-13:00 Steroid Hormone Receptors in Prostate Cancer: A Hard Habit to Break?Dr Gerhardt Attard, The Institute of Cancer Research and the Royal Marsden Hospital. Tuesday 27 October 2009, 12:00-13:00 "Phospholipase and lysophospholipase D signalling in cancer"Prof. Michael Wakelam, Institute Director, The Babraham Institute. Tuesday 20 October 2009, 12:00-13:00 "Immunostimulatory antibodies in cancer treatment"Prof. Peter Johnson, Professor of Medical Oncology, University of Southampton. Tuesday 13 October 2009, 12:00-13:00 Molecular Mechanisms of Cellular Senescence in Cancer and AgeingHutchison/MRC Research Centre Seminar Fabrizio d'Adda di Fagagna, IFORM-IEO, Milan. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 29 September 2009, 12:00-13:00 Clinical Aspects of Proton RadiotherapyProf Tony Lomax, Head of Medical Physics, Centre for Proton Radiation Therapy, Paul Scherrer Institute, Switzerland. Tuesday 15 September 2009, 12:00-13:00 Adoptive T Cell Therapy of CancerCassian Yee, Fred Hutchinson Research Center, Seattle. Tuesday 08 September 2009, 12:00-13:00 Genome scans in breast and prostate cancer - what have we learned & where next?Doug Easton, Strangeways Research Laboratory. Tuesday 30 June 2009, 12:00-13:00 Germ Cell Tumours (GCTs) of Young People: Clinical and Biological ApproachesJames Nicholson and Matthew Murray, Paediatrics, Addenbrooke's Hospital. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 23 June 2009, 12:00-13:00 Is brain cancer a stem cell disease?Colin Watts, Department of Clinical Neurosciences. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 16 June 2009, 12:00-13:00 Translational imaging studies in ovarian cancerJames Brenton, CRUK Cambridge Research Institute and Evis Sala, Department of Radiology. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 09 June 2009, 12:00-13:00 A model for all genomes: the role of RNA polymerases fixed in factoriesPeter Cook, University of Oxford. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 02 June 2009, 12:00-13:00 Using genetics to personalize melanoma therapyKeiran Smalley, Moffitt Cancer Center. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 26 May 2009, 12:00-13:00 Common germline variation and colorectal cancerRichard Hubner, Royal Marsden Hospital. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 19 May 2009, 12:00-13:00 Taming the tiger by the tail: modulation of DNA damage responses by telomeresDavid Lydall, Institute for Ageing and Health, Newcastle University. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 05 May 2009, 12:00-13:00 OPCML in Tumour Gene Therapy in Ovarian CancerHani Gabra, Faculty of Medicine, Imperial College London. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 28 April 2009, 12:00-13:00 Preservation of fertility in patients with cancerRaj Mathur (Addenbrooke's Hospital) and Tom Mathews (Medical Director, Bourn Hall). Tuesday 21 April 2009, 12:00-13:00 Connecting Lung Epithelial Stem Cells and Lung Cancer by Stress-Activated Protein KinasesJuan Jose Ventura, Wellcome Trust Centre for Stem Cell Research, University of Cambridge. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 07 April 2009, 12:00-13:00 Analysis of early events after DNA damage in living cells; the HP1 paradigmAnand Jeyasekharan, Hutchison/MRC Research Centre. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 31 March 2009, 12:00-13:00 What comes after cancer stem cells?Doug Winton, CRUK Cambridge Research Institute. Tuesday 24 March 2009, 12:00-13:00 Outreach chemotherapy programmePippa Corrie, Addenbrooke's Hospital. Tuesday 17 March 2009, 12:00-13:00 Radiation-induced bowel damage: let's put right what is wrongJervoise Andreyev, Royal Marsden Hospital. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 10 March 2009, 12:00-13:00 The spatial organisation of Ras signalingPhilippe Bastiaens, Max Planck Institute of Molecular Physiology, Germany. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 03 March 2009, 12:00-13:00 The role of cyclin-kinase inhibitors in the development of cancerNisar Malek, Hannover Medical School, Germany. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 24 February 2009, 12:00-13:00 Clinical potential of functional ion channel expression in cancerMustafa Djamgoz, Imperial College London. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 10 February 2009, 12:00-13:00 Role of the c-Myc-target gene Misu (NSun2) in regulating epidermal stem cell fate and its implications for cancerMichaela Frye, Wellcome Trust Centre for Stem Cell Research, University of Cambridge. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 03 February 2009, 12:00-13:00 Sarcomas and the insulin-like growth factor pathwayRobert Maki, Memorial Sloan-Kettering Research Center. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 27 January 2009, 12:00-13:00 The evidence for lifestyle after cancer to reduce relapse and survivalRobert Thomas, Addenbrooke's Hospital. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Tuesday 20 January 2009, 12:00-13:00 Patterns of stem and progenitor cell fate in adult tissuesProfessor Ben Simons, Department of Physics, Cambridge University. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 06 January 2009, 12:00-13:00 Title to be confirmedThis talk has now been postponed until next year Rebecca Fitzgerald, Cancer Cell Unit, Hutchison/MRC Research Laboratory. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 09 December 2008, 12:00-13:00 Delineating the Fanconi Anaemia DNA repair defectKJ Patel, MRC Laboratory of Molecular Biology. Sackler Lecture Theatre, CIMR, Level 7. Tuesday 02 December 2008, 12:00-13:00 The role of developmental biology in cancer researchAnna Philpott and Shin-ichi Ohnuma, Department of Oncology, MRC-Hutchison Research Centre. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 25 November 2008, 12:00-13:00 Colorectal neoplasia: what we know and don't know about genes and environmentJohn Potter, Fred Hutchinson Cancer Research Centre. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 18 November 2008, 12:00-13:00 The Editorial Process DemystifiedNote unusual time and venue Andrew Sugden, International Managing Editor, Science Magazine. Cancer Research UK Cambridge Research Institute, Lecture Theatre. Thursday 13 November 2008, 13:00-14:00 The West Anglia CLRN, TCRNs and the Coordinated System for gaining NHS Permission – How is it all going to work?Lena Pettersson, Lead RM and G Manager, West Anglia NIHR CLRN. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 11 November 2008, 12:00-13:00 The role of Fam38 in integrin activation and lung cancerTariq Sethi, Chair of Respiratory and Lung Cancer Biology, Centre for Inflammation Research, University of Edinburgh. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 28 October 2008, 12:00-13:00 High-throughput cancer cell line screening: a tool for discoveryUltan McDermott, Massachusetts General Hospital Cancer Center and Harvard Medical School. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 14 October 2008, 12:00-13:00 Title to be confirmedRichard Benson, Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 30 September 2008, 12:00-13:00 Title to be confirmedNick Carroll, Department of Radiology. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 23 September 2008, 12:00-13:00 Early phase clinical trials in CambridgeDuncan Jodrell, Cambridge Research Institute and Department of Oncology. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 16 September 2008, 12:00-13:00 Special seminar: Analysing the dynamic glycomePlease note that this lecture is on a Wednesday at the CRI. Lara Mahal, University of Texas, Austin. Wednesday 03 September 2008, 12:00-13:00 Chromatin modifying enzymes: their function and role in cancerTony Kouzarides, WT/CRUK Gurdon Institute. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 02 September 2008, 12:00-13:00 TBCGill Murphy, CRI and Charles Wilson, Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 24 June 2008, 12:00-13:00 Using Bayesian analysis in randomised phase II clinical trials to determine the worth of proceeding to phase IIICindy Billingham, University of Birmingham. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 17 June 2008, 12:00-13:00 'Mechanisms of tamoxifen action and resistance' and 'Cambridge Oncology - Past, Present & Future: A tour from the 18th to 21st Century'Jason Carroll, CRI and David Gilligan, Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 10 June 2008, 12:00-13:00 Taming Glioblastoma -Targeting Angiogenesis (CRI Special Seminar)Dr Steve Brem, Moffitt Cancer Center. Monday 09 June 2008, 13:00-14:00 Trials and Tribulations in the Management of Head and Neck CancerSarah Jefferies, Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 27 May 2008, 12:00-13:00 TBCPhil Jones, MRC Cancer Cell Unit, Hutchison-MRC Research Centre and Kate Fife, Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 20 May 2008, 12:00-13:00 TBCAdele Murrell, CRUK Cancer Research Institute and TBC. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 13 May 2008, 12:00-13:00 Targeting Hyperactive Ras and Uncovering Mechanisms of Therapeutic Resistance in Genetically Engineered MiceKevin Shannon, University of California San Francisco. Tuesday 29 April 2008, 12:00-13:00 Chromosome translocations and gene fusions in breast cancer and Improving outcomes in melanoma: a fresh lookPaul Edwards (Hutchison/MRC Research Centre) and Pippa Corrie (Addenbrooke's Hosptial, Clinical Oncologist, Lung and Upper GI Cancer). Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 22 April 2008, 12:00-13:00 Title to be confirmedHugo Ford, Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 15 April 2008, 12:00-13:00 Breast Cancer Heterogeneity and the Cancer Stem Cell HypothesisJohn Stingl, Cambridge Research Institute. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 08 April 2008, 12:00-12:30 Title to be confirmedErmanno Gherardi (MRC Laboratory of Molecular Biology) and Helena Earl (Medical Oncologist; Sarcoma, breast and ovarian cancer), Addenbrooke's Hospital). Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 25 March 2008, 12:00-13:00 'Monitoring anticancer drug uptake by magnetic imaging and spectroscopy' and 'Breast cancer heterogeneity- a clinical challenge'John Griffiths (CRUK Cambridge Research Institute) and Carlos Caldas (CRUK Cambridge Research Institute). Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 18 March 2008, 12:00-13:00 Title to be confirmedPaul Pharoah (Strangeways Research Laboratories) and Rajesh Jena (Addenbrooke's Hospital)). Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 11 March 2008, 12:00-13:00 Experimental manipulation of the epidermis to study normal and cancer stem cells and The GIST of GISTS (Gastrointestinal Stromal tumours)Fiona Watt, CRUK Cambridge Research Institute and Ramesh Bulusu, Clinical Oncologist (Lung/Upper GI/Lymphoma), Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 26 February 2008, 12:00-13:00 Title to be confirmedStefanie Reichelt (CR UK Cambridge Research Institute) and Sara Booth (Palliative Care), Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 19 February 2008, 12:00-13:00 Imaging biology in the cancer patient (K. Brindle)Kevin Brindle (CRUK Cambridge Research Institute and Department of Biochemistry) and Athar Ahmad (Medical Oncologist, Colorectal Tumours), Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 12 February 2008, 12:00-13:00 "Computational biology and cancer: the CRI perspective" and "Lung Cancer: A New Strategy"Simon Tavaré, CRUK Cambridge Research Institute and Tim Eisen, Medical Oncologist (Lung and Renal cancer), Addenbrooke's Hospital. Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 29 January 2008, 12:00-13:00 Acute Myeloid Leukaemia: Molecular Pathogenesis, Prognostication and Targeted therapy (Brian Huntly)Brian Huntly (Department of Haematology, Cambridge Institute of Medical Research) & Charles Crawley (Oncology Department, Addenbrookes Hospital). Alice Fisher Lecture Theatre, S Block, Addenbrooke's Site. Tuesday 22 January 2008, 12:00-13:00 Beyond VEGF: vascular signaling targets for therapeutic manipulationDavid Quinn, University of Southern California. Tuesday 18 December 2007, 12:00-13:00 Searching for and confirming common breast cancer risk alleles (Dunning) Update on Diet and Breast Cancer (Bingham)Alison Dunning & Sheila Bingham, Department of Oncology & MRC Dunn Human Nutrition Unit. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 04 December 2007, 12:00-13:00 Progress in prostate cancer and the androgen receptorDavid Neal and Ian Mills, CRUK Cambridge Research Institute. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 27 November 2007, 12:00-13:00 Title to be confirmedMargaret Stanley, Department of Pathology. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 20 November 2007, 12:00-13:00 "High throughput mapping of cis-regulatory DNA elements: From genomic arrays to functional biology" (George Follows) & "Rapid evolutionary turnover of transcription factor binding" (Duncan Odom)George Follows (Cambridge Institute for Medical Research) and Duncan Odom (CRUK Cambridge Research Institute). The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 13 November 2007, 12:00-13:00 Gain-of-function JAK2 mutations in the human myeloproliferative disordersLinda Scott (Cambridge Institute for Medical Research). The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 23 October 2007, 12:00-13:00 Proteins that license DNA replication (Laskey) Clinical exploitation of proteins that license DNA replication (Coleman)Ron Laskey and Nick Coleman (Hutchison-MRC Research Centre). The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 09 October 2007, 12:00-13:00 Title to be confirmedDavid Baulcombe, Sainsbury Lab, Norwich. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 18 September 2007, 12:00-13:00 Molecular genetics of MALT lymphoma: application in diagnosis and prognosis (Prof Ming Du), tbc (Prof Robert Marcus)Robert Marcus (Addenbrooke's Hospital) and Ming Du (University of Cambridge Department of Pathology). The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 11 September 2007, 12:00-13:00 "Targeting the Met receptor for cancer therapy" (Ermanno Gherardi) and "Preclinical efforts in Pancreatic Cancer" (Dave Tuveson)Ermanno Gherardi (MRC Laboratory of Molecular Biology) and Dave Tuveson (CRUK Cambridge Research Institute). The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 04 September 2007, 12:00-13:00 Targeting RET kinase activity as a novel therapeutic strategy for medullary thyroid carcinomaFrancesca Carlomagno, University of Naples. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 17 July 2007, 12:00-13:00 Developments in radiotherapy: new treatments for today and tomorrowNeil Burnet, Deptartment of Oncology. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 26 June 2007, 12:00-13:00 Exploiting senescence and anoikis in function-based oncogenomic screensHost: Ashok Venkitaraman Daniel Peeper, Netherlands Cancer Institute. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 19 June 2007, 12:00-13:00 Towards a fuller understanding of inherited susceptibility to colorectal cancerRichard Houlston, Institute of Cancer Research, Sutton. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 12 June 2007, 12:00-13:00 Novel mechanisms of clinical drug resistance in ovarian cancerJames Brenton, CRUK Cambridge Research Institute. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 05 June 2007, 12:00-13:00 Molecular heterogeneity of breast cancer - biological and clinical implicationsCarlos Caldas, CRUK Cambridge Research Institute. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 29 May 2007, 12:00-13:00 Experimental cancer medicine at the Dana Farber Cancer InstituteLee Nadler, Dana Farber Cancer Institute, Boston, USA. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 15 May 2007, 12:00-13:00 Germline genetic predictors of prognosis in breast cancerPaul Pharoah, Department of Oncology, Strangeways Research Laboratories. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 08 May 2007, 12:00-13:00 Dimethyl sulfoxide to vorinostat-targeted histone deacetylase inhibitor – mechanisms of action as an anti-cancer drugPaul Marks, Sloan-Kettering Institute, New York. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 01 May 2007, 12:00-13:00 RNAi Functional Analysis of Drug Resistance PathwaysCharlie Swanton, Cancer Research UK London Research Institute. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 24 April 2007, 12:00-13:00 Title to be confirmedMichael Wakelam, Babraham Institute. The Sackler Lecture Theatre, Level 7, Wellcome Trust/MRC Building, Addenbrooke's Site. Tuesday 17 April 2007, 12:00-13:00 Please see above for contact details for this list. |
Other listsThin Film Magnetism Group Seminars Marshall Holiday Lectures Computer Laboratory Programming Research Group SeminarOther talksPaediatric malignancies: an overview The race to solve the solar metallicity problem with neutrinos and discover dark matter Challenges to monetary policy in a global context Surrogate models in Bayesian Inverse Problems Organoid systems to study the maternal-fetal dialogue of early pregnancy Computing High Resolution Health(care) From Euler to Poincare DataFlow SuperComputing for BigData The Digital Doctor: Hope, Hype, and Harm at the Dawn of Medicine’s Computer Age Graph Legendrians and SL2 local systems Physico-chemical biology in practice, 1920s–1930s |