Neo-adjuvant radiochemotherapy in breast cancer

Add to your list(s) Download to your calendar using vCal

• Dr Alain Fourquet, Department of Radiation Oncology, Institut Curie, Paris
• Tuesday 13 December 2011, 12:00-13:00
• CRI Lecture Theatre.

If you have a question about this talk, please contact Mala Jayasundera.

Neo-adjuvant radiochemotherapy in breast cancer

Neaoadjuvant chemotherapy is currently offered to women with breast cancer too large to undergo breast-conserving surgery. Several randomised trials have demonstrated that neoadjuvant chemotherapy could allow a large proportion of women to preserve their breast, without impairing survival in comparison to mastectomy followed by adjuvant chemotherapy. Radiotherapy in a neoadjuvant setting has been used in the 70’s and ealy 80’s. A prospective randomised study had shown similar results between radiotherapy followed by mastectomy, or mastectomy followed by radiotherapy. Concurrent radiochemotherapy has demonstrated survival benefits in various tumor locations, such as oesophagus, anal canal, uterine cervix, lung, and head and neck. Two prospective randomised trials have shown that the concurrent delivery of radiotherapy and chemotherapy following breast-conserving surgery significantly reduced locoregional recurrence rates in patients with pN+ve tumors, in comparison with a sequential scheme. Concurrent neoadjuvant radiochemotherapy was used in the past in patients with locally advanced or inflammatory breast cancer with good clinical results in some. More recently, several phase II trials have investigated the efficacy of neoadjuvant concurrent radiotherapy and various chemotherapy combinations. This talk will present the results from Institut Curie series and review the available data in the literature. It will discuss the potential of concurrent radiochemotherapy schemes, and the interest of the use of targeted therapies with radiotherapy in breast cancer.

This talk is part of the Cambridge Oncology Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• CRI Lecture Theatre
• CRUK CI Seminars
• Cambridge Oncology Seminar Series
• Life Sciences
• Life Sciences
• ME Seminar
• MRC Cancer Unit Seminars
• PMRFPS's
• cancer
• cri
• my_list
• other talks
• se393's list
• sfm36

Note that ex-directory lists are not shown.