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Cell death and autophagy in response to inhibition of glycolysis

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If you have a question about this talk, please contact Dr Ireena Dutta.

Hutchison/MRC Research Centre Seminar

Tumor cells are highly glycolytic and depend on glucose for survival. Our laboratory is trying to understand how cells die when they lack glucose or when they are treated with 2-deoxyglucose, a non-metabolizable glucose analog. I will give an overview of work in our lab regarding the differences in cell death mechanisms induced by these treatments. I will also discuss the role of autophagy as a protective mechanism against selective nutrient deprivation or anti-metabolic treatments.

This talk is part of the Cambridge Oncology Seminar Series series.

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