|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
Cellular responses to DNA damage: translating molecular insights towards new cancer therapies
If you have a question about this talk, please contact Mala Jayasundera.
Inherited or acquired defects in detecting, signalling or repairing DNA damage are associated with various human pathologies, including immunodeficiencies, neurodegenerative diseases and cancer(1). Work in my laboratory aims to decipher the mechanisms by which cells detect DNA damage, signal its presence and mediate its repair(2). Much of our work focuses on DNA double-strand breaks (DSBs) that are generated by ionizing radiation and radiomimetic chemicals, and which also arise when the DNA replication apparatus encounters various forms of DNA damage. In this talk, I will summarize how our recent work has helped to establish how protein complexes assemble and disassemble on chromatin at sites of DNA damage and how these complexes promote DNA repair and DNA -damage signalling. I will also explain how our increasing knowledge of cellular DNA -damage responses is providing exciting opportunities for developing novel treatments for cancer(3). Finally, I will describe how the Cambridge-based company MISSION Therapeutics (http://www.missiontherapeutics.com/) plans to exploit these opportunities to produce new, more effective anti-cancer medicines.
References 1. Jackson, S.P. and Bartek, J. (2009). The DNA -damage response in human biology and disease. Nature 461, 1071-1078. 2. Polo SE and Jackson SP. (2011). Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev. 25, 409-433. 3. Jackson, SP. (2009). The DNA -damage response: new molecular insights and new approaches to cancer therapy. Biochem. Soc. Trans. 37, 383-394
This talk is part of the Cambridge Oncology Seminar Series series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsHomerton Seminars CISA Panel on 2013 Italian Elections Institute of Theoretical Geophysics Informal Lunchtime Seminars (DAMTP)
Other talksA Natural History of Sentience From Cambridge to Cuzco and back again: 4000 years of environmental history from the heart of the Inca Empire Towards General Artificial Intelligence Firmament: fast, centralized cluster scheduling at scale PAC learning Adrian Seminar Series - Annual Lecture "How Do You Feel? Ion channels that sense mechanical force"