Tracking genomic aberrations of the androgen receptor (AR) in castration-resistant prostate cancer (CRPC)

Add to your list(s) Download to your calendar using vCal

• Dr Gerhardt Attard, Royal Marsden Hospital, London
• Tuesday 18 November 2014, 12:00-13:00
• CRUK CI Lecture Theatre.

If you have a question about this talk, please contact Mala Jayasundera.

Host: Dr Simon Pacey

Next-generation sequencing of circulating plasma DNA from CRPC offers an opportunity to monitor tumor genomic aberrations over the course of the disease. These studies have identified multiple independent clones with distinct genomic patterns showing complex dynamics over the lethal course of prostate cancer, partially related to treatment selection pressure. Clones harboring resistance-conferring AR mutations emerge in approximately 20% of patients treated with abiraterone and exogenous corticosteroids. These mutations are activated by ligands that persist in abiraterone-treated patients, including by prednisolone or dexamethasone at clinically relevant doses, and confer a survival advantage. Often sub-clones with alternative genomic aberrations, including AR amplification, are also present suggesting multiple mechanisms co-exist that lead to re-activation of AR signaling. These data introduce a management paradigm requiring sequential monitoring of advanced prostate cancer patients with plasma and tumor biopsies to ensure early discontinuation of agents when they become potential disease drivers and identify therapeutic targets that will allow selection of the next best treatment.

This talk is part of the Cambridge Oncology Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• CRUK CI Lecture Theatre
• CRUK CI Seminars
• Cambridge Oncology Seminar Series
• Life Sciences
• Life Sciences
• ME Seminar
• MRC Cancer Unit Seminars
• PMRFPS's
• cancer
• cri
• my_list
• other talks
• se393's list
• sfm36

Note that ex-directory lists are not shown.