Biomolecular self-assemblies by solid-state NMR: functional amyloids and bacterial filaments

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• Dr Birgit Habenstein, CBMN UMR5248 CNRS, Institut de Biologie & Chimie des Membranes & Nanoobjets
• Wednesday 19 July 2017, 10:30-11:30
• Department of Chemistry, Cambridge, Unilever lecture theatre.

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Macromolecular self-association plays a fundamental role in numerous biological processes ranging from host-pathogen interaction, viral infection to the propagation of neurodegenerative disorders. The assembled objects contain multiple protein subunits non-covalently arranged in supramolecular architectures that can execute a variety of cellular functions or cause detrimental consequences. Despite the large arsenal of biophysical approaches it remains a major challenge to provide atomic details on the assembled structures and the mechanisms involved in their assembly and function. Magic angle spinning solid-state NMR emerges as a powerful and versatile technique to reveal structures, dynamics and inter-molecular interactions in large macromolecular assemblies at the atomic scale without being limited by the size or the microscopic homogeneity of the objects. I will present MAS solid-state NMR methods and their application to two different types of molecular objects of pharmaceutical interest. I will concentrate on the insights we can obtain on functional amyloids involved in cell-death signaling but I will also introduce SSNMR approaches to discern structures of molecular machines involved in bacterial infection, the type 1 pilus and the type III secretion system needle.

This talk is part of the Biophysical Seminars series.

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