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Lattice models for DNA origami self-assembly

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1st Year PhD Report

DNA origami is a class of highly designable, self-assembling structures with myriad potential applications in both medical and non-medical fields. The assembly process of these systems, which involves the binding of a number of short staple strands to a longer scaffold strand, has not been fully characterized, and current models capable of studying the process are either computationally intractable or lack important features. In this talk, I will discuss a new class of models for DNA origami we have been developing that attempt to bridge this gap by representing the systems on a lattice at the level of binding domains and using simulation methods that allow explicit simulation of free staple strands to be avoided.

This talk is part of the Theoretical Chemistry Informal Seminars series.

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