Dangerous Liaisons between platelets and cancer

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• Anil Sood, MD - University of Texas, MD Anderson Cancer Centre
• Thursday 14 December 2017, 13:00-14:00
• CRUK CI Lecture Theatre.

If you have a question about this talk, please contact Kate Davenport.

Platelets are well known to serve as “first responders” during normal wounding and homeostasis. However, it is becoming increasing clear that these anucleate platelets can influence several pathological processes including cancer. Tumor derived factors can drive megakaryopoiesis, resulting in paraneoplastic thrombocytosis. Additionally, thrombocytosis in cancer patients is associated with adverse patient survival. Experimental evidence has highlighted the roles of platelets as important and active factors in many steps of tumorigenesis including tumor growth, extravasation of tumor cells and metastasis. Platelets can infiltrate into the tumor microenvironment to increase proliferation and inhibit apoptosis of cancer cells. By secretion of large amounts of microparticles and exosomes, platelets are well positioned to coordinate both local and distant tumor-host crosstalk. In this presentation, I will present recent discoveries related to the role of platelets in cancer progression.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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