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How the sins of your grandparents affect your health

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Environmental exposure to stressors, such as dietary deficiency, might have an impact on epigenetic regulation of gene expression. This may increase your risk for disease over the course of your lifetime. Recent studies show that this disease risk might be epigenetically inherited between generations via the germline, affecting the health and development of your grandprogeny and great grandprogeny. Our research uses a mouse model of abnormal folate metabolism to understand the epigenetic mechanism behind transgenerational inheritance of developmental phenotypes. Not only does this work shed light onto the role of folate metabolism during development, which has eluded researchers for decades, but it also give us new insight into disease prevention methods, the effects of which may not be observed for multiple generations

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