University of Cambridge > > Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer > Understanding and targeting the ovarian cancer microenvironment

Understanding and targeting the ovarian cancer microenvironment

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The aim of our current work is to deconstruct the tumour microenvironment of ovarian cancer metastases in order to inform in vitro and in silico modelling of this disease and to aid testing of new biological therapies. Specifically, we are conducting high resolution profiling of the evolving tumour microenvironment of omental metastases of human high-grade serous ovarian cancer, HGSC . We have analysed higher order structures of omental metastases, architecture, cellularity and biomechanical properties, and related these to transcriptomic and proteomic data on the same sample using multivariate analysis. This has allowed us to identify gene and protein expression patterns that best predict the higher order structures. Our results suggest that investigation of multiple aspects of the evolving tumour may be useful in generating more representative models of its microenvironment, providing information that complements data obtained from studying a single parameter in larger numbers of biopsies.

This talk is part of the Cancer Research UK Cambridge Institute (CRUK CI) Seminars in Cancer series.

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