Pathways of protein quality control in the cytosol

Add to your list(s) Download to your calendar using vCal

• Dr. Ramanujan Hegde, LMB Cambridge
• Wednesday 04 November 2015, 10:30-11:30
• Department of Chemistry, Cambridge, Unilever lecture theatre.

If you have a question about this talk, please contact Jerome Charmet.

Approximately 25% of all genes encode integral membrane proteins that must be selectively targeted to and inserted into various intracellular membranes. These hydrophobic membrane proteins must necessarily transit the cytosol en route to their final destination. Our group has been investigating how cytosolic factors shield these membrane proteins to prevent aggregation and how they are correctly targeted to their final destination. These destinations include the endoplasmic reticulum, mitochondria, or the proteasome. Over the past several years, we have begun to identify and analyze the factors involved in membrane protein traffic and degradation in the cytosol. These include the factors for tail-anchored membrane protein targeting to the ER and degradation factors for elimination of mis-targeted membrane proteins. We are now dissecting the inter-relationships between these various factors to determine how membrane proteins are triaged appropriately to maintain cytosolic protein homeostasis.

This talk is part of the Biophysical Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biophysical Seminar Series 2016/17
• Biophysical Seminars
• Department of Chemistry
• Department of Chemistry, Cambridge, Unilever lecture theatre
• Featured lists
• School of Physical Sciences

Note that ex-directory lists are not shown.