University of Cambridge > Talks.cam > BRC Seminar Series > "A subclass of neocortical fast spiking parvalbumin (FS-PV) interneurons enwrapped by PeriNeuronalNet (PNN) expresses ADAMTS peptidases. Possible roles of these metallo-peptidases in plasticity and critical period."

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"A subclass of neocortical fast spiking parvalbumin (FS-PV) interneurons enwrapped by PeriNeuronalNet (PNN) expresses ADAMTS peptidases. Possible roles of these metallo-peptidases in plasticity and critical period."

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The in situ hybridization Allen Mouse Brain Atlas was mined for proteases expressed in the somatosensory cerebral cortex. Among the 480 genes coding for protease/peptidases, only 3 were found enriched in cortical interneurons: Adamts8 and Adamts15 belonging to the class of metzincin proteases involved in reshaping the perineuronal net (PNN) and Mme encoding for Neprilysin, the enzyme degrading amyloid β−peptides. The pattern of expression of metalloproteases (MP) was analyzed by single cell RT multiplex PCR after patch-clamp and was compared with the expression of 10 canonical interneurons markers and 12 additional genes from the Allen Atlas. Clustering of these genes by K-means algorithm displays five distinct clusters. Among these 5 clusters, two fast spiking (FS) interneurons clusters expressing the calcium-binding protein Pvalb were identified, one co-expressing Pvalb with Sst (PV-Sst) and another co-expressing Pvalb with three metallopeptidases Adamts8, Adamts15 and Mme (PV-MP). PV-MP interneurons were found surrounded by PNN while the one expressing Sst, PV-Sst were not. These observations will be discussed in view of current hypothesis on brain plasticity, critical period and long term memory .

This talk is part of the BRC Seminar Series series.

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