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Idas and Lynkeas control Radial glial cells commitment to ependymal lineage

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If you have a question about this talk, please contact Shannon Tinley-Browne.

A small subpopulation of Radial glial cells, contributes to the generation of adult neural stem cells and multiciliated ependymal cells, which reside in the subependymal zone at lateral walls of the adult cortex. We provide evidence that Idas and Lynkeas, two novel proteins sharing homology with Geminin, are the earliest known marker of radial glial cells committed to the ependymal cell lineage in the developing mouse brain. RGs upon Idas or Lynkeas overexpression loss their neural stem cells characteristics and prematurely differentiated into multiciliated ependymal cells, while inactivation experiments resulted in blockage of multiciliated ependymal cells generation. We have also shown that Idas and Lynkeas act upstream of known transcription factors essential for the commitment and differentiation of RGs towards ependymal cells, while they are negatively regulated by Notch pathway. Our results suggest that Idas and Lynkeas are key players for radial glial cells fate commitment and differentiation to multiciliated ependymal cells.

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