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Finding Shared Causal Variants Between Diseases

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Part of the TCSS Symposium

We know that there are many genetic loci associated with multiple autoimmune diseases. However demonstrating that a variant is associated with two traits is insufficient to establish causality for both; the true causal variants may be distinct but in linkage disequilibrium. I developed a statistical test to study whether two diseases share distinct or common variants in a given genetic region. By using this algorithm to leverage information across datasets, I was also able to identify novel disease associations.

This talk is part of the Trinity College Science Society (TCSS) series.

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