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University of Cambridge > Talks.cam > Cambridge University Biological Society > G-quadruplex: the DNA quadruple helix
G-quadruplex: the DNA quadruple helixAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Ivan Lam. This talk is free for members of BioSoc or £2 for non-members. You can also sign up for life membership (£15) at this talk. DNA is structurally dynamic in ways that have a consequence for biological processes. In this lecture I will discuss a class of four-stranded DNA structure, called the G-Quadruplex that can be formed from G-rich single stranded DNA . There is now a good level of understanding on the structural biophysics of G-quadruplexes along with a large body of work on the design and synthesis of small organic molecules that can target such structures. Some such molecules have been found to have anti-proliferative effects on human cancer cells along with specific effects on the activity of certain genes, raising intriguing hypotheses about their existence and function in cells. I will present recent results from my laboratory that provide new insights into when and where such non-Watson-Crick structures may exist in cellular DNA together with a perspective on whether this structural motif in DNA presents new opportunities to think about intervention and future therapeutics. This talk is part of the Cambridge University Biological Society series. This talk is included in these lists:
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