University of Cambridge > Talks.cam > BRC Seminar Series > Insights in the metabolic control of T cell migration and function: implications for immune inflammation in metabolic diseases

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Insights in the metabolic control of T cell migration and function: implications for immune inflammation in metabolic diseases

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact David Williamson.

Metabolic diseases, including atherosclerosis, obesity and diabetes, and arthritis are a leading cause of morbidity. Low-grade T cell-mediated inflammation is associated with these conditions and contributes to their pathogenesis and progression. Our current studies indicate that interfering with metabolic pathways (i.e., lipid, glucose and oxidative metabolism) alters T cell trafficking and function in vitro and in vivo. The major hypothesis we are investigating is that metabolic alterations lead to aberrant T cell migration patterns, which favour the establishment of chronic inflammation. We are exploring the mechanisms of metabolic control of T cell migration in physiology and under metabolic stress. We are also investigating the effect of drugs that correct altered metabolism (e.g., the antidiabetic drug metformin) on T cell trafficking and inflammation in murine models of obesity. These studies will provide insights into the role of energy balance on physiologic T cell trafficking and the effect of altering metabolism on the development of T cell-mediated inflammation.

This talk is part of the BRC Seminar Series series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Cambridge Experimental and Behavioural Research Group (CEBEG) https://data.mendeley.com/datasets?... Traduire cette page N Boudemagh. N Boudemagh. Contribution: PhD, network ASSET MANAGEMENT. 07 Nov 2016 in: Smart Transportation. aPPLIED MATHEMA. Viewed. Cambridge Neuroscience Symposium - Ion Channels in Health and Disease Friends of Cambridge University Library All CRASSH events Inference Group

Other talks

Scale and anisotropic effects in necking of metallic tensile specimens CANCELLED: The cognitive neuroscience of antidepressant drug action Climate Change: Engaging Youth On being a "barang": Experiences of interviewing fishermen in Cambodia and Indonesia Borel Local Lemma Cambridge-Lausanne Workshop 2018 - Day 1 Art and Migration Unbiased Estimation of the Eigenvalues of Large Implicit Matrices Throwing light on organocatalysis: new opportunities in enantioselective synthesis "Mechanosensitive regulation of cancer epigenetics and pluripotency" EMERGING EPIGENETICS: DETECTING & MODIFYING EPIGENETICS MARKS
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity