University of Cambridge > > MRC Mitochondrial Biology Unit Seminars > Mitochondria and the cytoskeleton – matters of life and death in the face of stress

Mitochondria and the cytoskeleton – matters of life and death in the face of stress

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Cell survival in the face of stress relies upon linking the perception of change to appropriate downstream responses. The actin cytoskeleton, in addition to its better known role as a cellular scaffold, is emerging as an important co-ordinator of stress perception and response. Of particular note appears to be the conserved role that actin plays in regulating mitochondrial function in response to a variety of stresses. This relationship can be utilised to engage the mitochondria within newly discovered retrograde signalling pathways, or to initiate apoptosis. Using the model eukaryote S. cerevisae we have identified new pathways that link the health of both the actin cytoskeleton and the mitochondria to environmental responses that determine cell fate.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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