University of Cambridge > > Plant Sciences Departmental Seminars > From Clone to Clinic- oilseed based bio-pharmaceutical production

From Clone to Clinic- oilseed based bio-pharmaceutical production

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This is a CPPS Seminar

Recombinant human Insulin, including its analogues, is the largest volume protein pharmaceutical that is manufactured worldwide. It has a current market value in excess of $8 billion, with a demand that is growing due to increasing incidence of Type II diabetes worldwide and the improved detection of the condition in highly populated, but underserved countries. All commercial recombinant insulin is made in microorganisms, either in E. coli or yeast. Although the manufacturing process has been greatly streamlined over the past 20 years, the cost of goods (COGs) is still a significant factor in supplying the developing world with its necessary supply of Insulin. Furthermore, the capital cost of a conventional fermentation facility for Insulin is still a major disincentive for construction in undersupplied countries. Plants offer the possibility to meet these cost constraints in the production of Insulin and the construction of the necessary facilities. Plant-based production could decrease the COGs for Insulin by 40-50% and the capital cost of a facility by as much as 70%. We have used the oilseed plant Safflower as a platform for the expression of a recombinant proinsulin, which can be recovered inexpensively from the seeds using oilbody separation as a key step in the recovery and enrichment. This approach could allow inexpensive bulk production and purification under cGMP conditions. The plant-derived proinsulin is matured into Insulin chemically and biochemically identical to commercially available Insulin. We have furthermore shown in human clinical trials that plant-made insulin is bioequivalent to Humulin-R, a predominant form of insulin prescribed in N. America.

This talk is part of the Plant Sciences Departmental Seminars series.

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