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Dissecting mechanisms controlling somatic cell reprogramming

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If you have a question about this talk, please contact Shannon Tinley-Browne.

Research Interests: Whether somatic cell reprogramming can occur in vivo in higher vertebrates and the molecular mechanisms driving reprogramming remain to be defined. Activation of the Wnt/β-catenin signalling pathway enhances reprogramming of somatic cells after their fusion with ESCs. Wnt signalling also controls regeneration in response to damage in lower and higher vertebrates. Our main goals is to dissect mechanisms of somatic cell reprogramming and to determine whether activation of Wnt/β-catenin signalling controls tissue regeneration by enhancing cell fusion-mediated reprogramming.

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