University of Cambridge > > Immunology in Pathology > Macrophage paired receptors - structure, interactions and evolution

Macrophage paired receptors - structure, interactions and evolution

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Sue Griffin.

Host: Jim Kaufman,

Paired receptors are families of membrane proteins that have very similar extracellular regions but different intracellular regions and signalling potential.

This paradox has been investigated by determining the fine structure of the members of the SIRP paired receptors family and a ligand CD47 . These structures indicate the molecular basis for the fine specificity of SIRP alpha and also to the evolution of antigen receptors. The combination of genetic analysis and structural data suggests molecular mechanisms for how pathogens are driving the rapid evolution of paired receptors and how the environment may be modulating immune responses.

This talk is part of the Immunology in Pathology series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2024, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity