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CATEGORIES:Immunology in Pathology
SUMMARY:Macrophage paired receptors - structure\, interact
 ions and evolution - Professor Neil Barclay\, Univ
 ersity of Oxford
DTSTART;TZID=Europe/London:20110511T123000
DTEND;TZID=Europe/London:20110511T133000
UID:TALK30772AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/30772
DESCRIPTION:Paired receptors are families of membrane proteins
  that have very similar extracellular regions but 
 different intracellular regions and signalling pot
 ential. \n\nThis paradox has been investigated by 
 determining the fine structure of the members of t
 he SIRP paired receptors family and a ligand CD47.
  These structures indicate the molecular basis for
  the fine specificity of SIRP alpha and also to th
 e evolution of antigen receptors. The combination 
 of genetic analysis and structural data suggests m
 olecular mechanisms for how pathogens are driving 
 the rapid evolution of paired receptors and how th
 e environment may be modulating immune responses.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis
  Court Road
CONTACT:Sue Griffin
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