Emergence of HIV drug resistance during combinational therapy.

Add to your list(s) Download to your calendar using vCal

• John Kitayimbwa
• Thursday 20 May 2010, 16:30-17:30
• Meeting Room 14, Centre for Mathematical Sciences.

If you have a question about this talk, please contact Olivier Restif.

We investigate the factors that determine the emergence of a drug-resistant HIV strain during the course of combination therapy. Using a within-host model for the dynamics of HIV , we study conditions under which mutant variants are selected in the presence of drug pressure and dominate the virus population. Local and global stability of resultant equilibrium points are discussed. An optimal combinational treatment regime that seeks to maximize the benefits of treatment while minimizing viral loads and side effects of the treatment regimen involved is explored. Preliminary results suggest that an optimal length of “drug holiday” can be found, which makes structured treatment plausible in the administration of ART .

This talk is part of the Worms and Bugs series.

This talk is included in these lists:

• All CMS events
• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Diseases
• Meeting Room 14, Centre for Mathematical Sciences
• Worms and Bugs
• bld31

Note that ex-directory lists are not shown.