University of Cambridge > Talks.cam > Foster Talks > Molecular mechanisms that regulate the first cell fate decisions in human development

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Molecular mechanisms that regulate the first cell fate decisions in human development

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact foster.

During preimplantation development human embryos are comprised of pluripotent embryonic cells, which eventually form the fetus, and extra-embryonic cells, which contribute to the placenta and yolk sac. The central question we address is what are the molecular mechanisms that regulate these early cell fate choices in human embryos. We are using CRISPR /Cas9-mediated genome editing, TRIM -Away protein depletion, dominant negative mutations and small molecules to dissect the function of genes during human embryogenesis. These methods have enabled us to uncover that the first lineage specification event in human embryos is the initiation of a placental program and that the second decision is the differentiation of yolk sac progenitor cells. Our work has also uncovered a high frequency of unintended on-target mutations following genome editing in human primary cells. By integrating signalling insights from human blastocysts we have defined human embryonic stem cell culture conditions that more closely recapitulate the embryonic niche. The molecular basis of these early cell lineage decisions are of fundamental importance and have wide-reaching clinical implications for infertility, miscarriages, developmental disorders and therapeutic applications of stem cells.

This talk is part of the Foster Talks series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Research Reports Events Type the title of a new list here Computer Science Careers Events

Other talks

Novel approaches to Hydrogen, CO2 Conversion and Ammonia to reduce carbon emissions LLM Generalization in Social Context CSAR lecture: Is recycling just a load of rubbish? Precision Under Pressure: The Growing Role of Formal Specifications in Shaping the Nuclear Industry's Future Executable Separation Logic Specifications in CN Operator Algebras
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity