Mechanisms that Contribute to Proteostasis Collapse in Aging and Disease

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• Prof Richard I. Morimoto, Department of Molecular Biosciences, Rice Institute of Biomedical Research, Northwestern University, USA
• Thursday 09 March 2023, 11:15-12:15
• Department of Chemistry, Unilever Lecture Theatre.

If you have a question about this talk, please contact Alyssa Miller.

Proteostasis and the regulation of cellular protein quality control mechanisms are essential for the stability and function of the entire proteome and cellular health and organismal lifespan. Consequently, proteostasis collapse in aging represents an initiating programmed event in biology that promotes protein misfolding, mislocalization, aggregation of proteins. In turn, these events interfere with the stability, composition and stoichiometry of the proteome leading to amplification of dysregulated cellular processes. We employ genetic, biochemical and proteomic methods to understand how proteome stability is achieved, to establish the molecular basis of proteostasis collapse and to understand the underlying complexity and magnitude of proteome instability in stress, aging and disease.

This talk is part of the Biophysical Seminars series.

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