Designing multiphase biomolecular condensates

Add to your list(s) Download to your calendar using vCal

• Pin Yu Chew, University of Cambridge
• Wednesday 16 November 2022, 14:30-15:00
• Wolfson Lecture Theatre, Dept of Chemistry and Zoom.

If you have a question about this talk, please contact Lisa Masters.

First Year PhD Report https://zoom.us/j/97189750171?pwd=RlppL21lSFJnVkwwSG4xeTE3a0NWQT09 Meeting ID: 971 8975 0171 Passcode: 320880

Biomolecular condensates are highly multi-component systems in which complex phase behaviour can ensue, including the formation of architectures comprising multiple immiscible condensed phases. Relying solely on physical intuition to manipulate them is difficult because of the complexity of their composition. We address this challenge by developing a computational approach which couples a genetic algorithm to a residue-resolution coarse-grained protein model to design pairs of protein sequences that result in well-separated multilayered condensates. We find that the balance of homo- and heterotypic interaction energies between the two components is important for controlling multiphase organisation, and our approach for designing multilayered condensates achieves this balance of interaction energies by optimising the composition and patterning of the protein sequences.

This talk is part of the Theory - Chemistry Research Interest Group series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Department of Chemistry
• Featured lists
• Lennard-Jones Centre external
• School of Physical Sciences
• Wolfson Lecture Theatre, Dept of Chemistry and Zoom

Note that ex-directory lists are not shown.