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Supramolecular Peptide Assemblies For Functional Systems

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Our research group is interested in the application of supramolecular chemistry to understand and manipulate biology.[1,2] Our work philosophy is based in the importance of weak and non-covalent forces to control the shape and the topology of biomolecules, which are governed by the principles described by supramolecular chemistry. These supramolecular lessons can then be applied to control the properties and function of biomolecules. We believe that by modulating the shape we can mimic, control and improve functional behaviour. With focus in supramolecular interactions for artificial membranes and tubular composites, we investigate the construction of synthetic systems for controlling and emulating biology and life-like soft systems.[3-5]

References [1] General review: A. Fuertes, J. Marisa, J. R. Granja, J. Montenegro, Chem. Commun. 2017, 53, 7861–7871. [2] Delivery review: I. Lostalé-Seijo, J. Montenegro, Nat. Rev. Chem. 2018, 2, 258–277. [3] Membrane transport and delivery applications: a) J. M. Priegue, D. N. Crisan, J. Martínez- Costas, J. R. Granja, F. Fernandez-Trillo, J. Montenegro, Angew. Chem. Int. Ed. 2016, 55, 7492– 7495. b) I. Lostalé-Seijo, I. Louzao, M. Juanes, J. Montenegro, Chem. Sci. 2017, 8, 7923–7931. c) 1.Barba-Bon, A. et al. Nature, 2022, 603, 637–642. [4] Synthetic supramolecular biocomposites: a) I. Insua, J. Montenegro, J. Am. Chem. Soc. 2020, 142, 1, 300-307, b) A. Méndez-Ardoy, J. R. Granja, J. Montenegro, Nanoscale Horizons, 2018, 3, 391-396. c) Méndez-Ardoy, A. et al. Angew. Chem. Int. Ed. 2020, 59, 6902–6908. d) 1.Booth, R., Insua, I., Ahmed, S., Rioboo, A. & Montenegro, J. Nat Commun. 2021, 12, 6421.

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