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SARS-CoV-2 evolution: (Dis)entangled on multiple scales

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If you have a question about this talk, please contact Dr Ciara Dangerfield.

Evolutionary epidemiology is shaped by causes that span multiple orders of magnitude. For example: The fates of novel SARS -CoV-2 variants depend on the societal interventions implemented, while in turn those interventions are often direct reactions to adapted virus phenotypes. In order to study certain aspects of this coupling, we have developed a computational model, which incorporates stochastic evolutionary events into an epidemiological setting. We show that a combined effort of vaccination and non-pharmaceutical interventions is most effective at keeping a pathogen from evolving vaccine resistance. This effect is further facilitated by societal aspects, such as a greater diversity of vaccines distributed, a fast paced vaccine development and distribution as well as low levels of vaccine hesitancy. But also on the end of small scales, biochemical aspects shape the viral fitness landscape and will influence the success of a vaccination campaign.

This talk is part of the Worms and Bugs series.

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