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Development Of A Multiscale Chromatin Coarse-Grained Model

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First Year PhD Report

In eukaryotic cells DNA is organised in the form of nucleosomes. An array of nucleosomes connected by linker DNA is known as chromatin. Chromatin is organised across functionally different domains spanning Kb to Mb scales. In this study we investigate chromatin composition and organisation in vitro and in vivo and highlight some results of the intrinsic organisation of chromatin as a function of nucleosome repeat length and how these results relate to experimental studies on chromatin liquid-liquid phase separation. We also study the effect of the H1 linker histone on our chromatin model and highlight that it increases chromatin compaction by acting as a liquid like glue for chromatin.

This talk is part of the Theory - Chemistry Research Interest Group series.

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