University of Cambridge > Talks.cam > Biophysical Seminars > Probing proteome foldedness and conformational changes under proteostasis stresses

Probing proteome foldedness and conformational changes under proteostasis stresses

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Kimberley Callaghan.

The Hatters lab studies impacts of protein misfolding and aggregation in cultured cell models of neurodegenerative diseases. We have developed approaches to examine the changes in solubility of the proteome in context of Huntington’s disease cell models and when we perturb specific elements of the quality control systems that regulate proteostasis. We have also developed approaches with chemical reagents to monitor cysteine reactivity to probe changes in proteome foldedness and conformation. I will discuss recent findings from our laboratory including unpublished work that provide insight to the mechanisms of how proteins in cells change their structure and function in response to stresses and stimuli.

This talk is part of the Biophysical Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2021 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity