The switch from choice to commitment: an example from HIV

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• Dr. Maike Hansen, Radboud University Nijmegen
• Wednesday 28 April 2021, 10:30-11:30
• https://zoom.us/j/92521025039.

If you have a question about this talk, please contact Anne Jacobs.

Gene expression is an example of a complex multistep cellular reaction, where variability in reaction outcome can convey distinct phenotypic properties. Results show that about 85% of genes across diverse promoters, genomic loci, and cell types (human and mouse) exhibit a high degree of rate-driven noise amplification. An additional cytoplasmic noise-amplification step leads to large variability in protein levels. This raises the important question of how efficient noise attenuation can be achieved, for example during human immunodeficiency virus (HIV) fate-commitment. Our data reveals that after a noise-driven event, HIV implements an efficient post-transcriptional negative-feedback which minimizes gene expression variability and stabilizes viral fate.

This talk is part of the Biophysical Seminars series.

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• https://zoom.us/j/92521025039

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