University of Cambridge > Talks.cam > Biophysical Seminars > Stabilization of Protein-Protein Interactions; from biophysical concept to medicinal chemistry application

Stabilization of Protein-Protein Interactions; from biophysical concept to medicinal chemistry application

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Anne Jacobs.

Our group combines organic synthesis, protein chemistry, structural biology, and supramolecular chemistry to perform chemical biology studies on protein-protein interactions (PPIs) with the aim to enable innovative medicinal chemistry for ‘molecular glues’ for PPIs. In this presentation I aim to show that a “supramolecular” point of view to protein-protein interactions (PPIs) helps to unravel the underlying, more complex, interaction mechanisms. This conceptual approach to PPIs allows to recognize and apply concepts such as multivalency and cooperativity within the context of drug discovery. Using nuclear receptors and 14-3-3 proteins as examples this presentation aims to provide insights into questions such as 1) How can chemical biology studies steer medicinal chemistry for PPIs? 2) What are the key biophysical characteristics of molecules that stabilize PPIs? 3) How can we find chemical starting point for PPI stabilization?

This talk is part of the Biophysical Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2021 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity