Conformational control: From single molecules to biotechnologies

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• Prof. Taekjip Ha, Johns Hopkins University
• Wednesday 17 February 2021, 16:00-17:00
• https://zoom.us/j/97411702169?pwd=c3JEeVBWemdQb3FHeGc0Smk3M2ZiQT09.

If you have a question about this talk, please contact Anne Jacobs.

Proteins have multiple conformations with distinct functional roles. How the conformations interconvert to regulate function is an active area of research. We have been studying two classes of DNA unwinding enzymes, CRISPR Cas9 and helicases, and how their activities are regulated by conformational control. We have used the mechanistic knowledge to engineer new variants of the enzymes that can be activated through light or chemical crosslinking. I will describe several biotechnological applications, including precision genome manipulation in time and space, co-transcriptional RNA folding, isothermal DNA amplification and genome imaging.

This talk is part of the Biophysical Seminars series.

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• All Talks (aka the CURE list)
• Biophysical Seminar Series 2016/17
• Biophysical Seminars
• Department of Chemistry
• Featured lists
• School of Physical Sciences
• https://zoom.us/j/97411702169?pwd=c3JEeVBWemdQb3FHeGc0Smk3M2ZiQT09

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