University of Cambridge > > Biophysical Seminars > Glutamate receptors: from single molecules to physiology

Glutamate receptors: from single molecules to physiology

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Akhila Kadgathur Jayaram.

Glutamate receptors mediate excitatory responses in the mammalian central nervous system, and ultimately control motor and cognitive functions. AMPA mediate fast synaptic transmission by opening cation ion permeable channels upon binding glutamate. We use a combination of mutagenesis, single molecule FRET and luminescence resonance energy transfer methods, along with electrophysiological measurements to map the conformational landscape that the underlies this gating process of channel opening and desensitization in this protein. We also investigate how the gating properties are modulated by the presence auxiliary subunits such as gamma2 and gamma 8, as well as small molecule inhibitors, and determine the changes in the conformational landscape that underlie these modulatory functional changes.

This talk is part of the Biophysical Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2024, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity