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University of Cambridge > Talks.cam > Biophysical Seminars > Determination of protein structure and dynamics with integrative approaches
Determination of protein structure and dynamics with integrative approachesAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Gabriella Heller. Cryo-electron microscopy is rapidly emerging as a powerful technique to determine the structures of complex macromolecular systems elusive to other techniques. Since many of these systems are highly dynamical, characterizing also their movements is a crucial step to unravel their biological functions. In this talk, I will present an integrative modelling approach to simultaneously determine structure and dynamics from cryo-electron microscopy density maps. By quantifying the level of noise in the data and dealing with their ensemble-averaged nature, this approach enables the integration of multiple sources of information to model ensembles of structures and infer their populations. I will illustrate the method with two examples: the characterization of structure and dynamics of the ClpP protease by a combined cryo-EM and NMR approach and the study of the effect of acetylation on microtubule structure and stability. This talk is part of the Biophysical Seminars series. This talk is included in these lists:
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