University of Cambridge > > Adrian Seminars in Neuroscience > It takes two to tango: The cerrebellum simplified into two types of modules with two encoding schemes

It takes two to tango: The cerrebellum simplified into two types of modules with two encoding schemes

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1.Gao et al., 2012 Nature Reviews and De Zeeuw et al., 2011 Nature Reviews

2.Detlef, H. H. & De Zeeuw, C. I. et al., J Neuroscience 2013.

3. Detlef, H.H., De Zeeuw, C.I., Jaeger, D., Khodakhan, K., & Person, A.L. 2013 The Neuronal Code(s) of the Cerebellum. The Journal of Neuroscience. 33(45): 17603-17609; doi: 10. 1524/jNeuroscience. 2757-13. 2013.

Abstract Understanding how neurons encode information in sequences of action potentials is of fundamental importance to neuroscience. The cerebellum is widely recognized for its involvement in the coordination of movements, which requires muscle activation patterns to be controlled with millisecond precision. Understanding how cerebellar neurons accomplish such high temporal precision is critical to understanding cerebellar function. Inhibitory Purkinje cells, the only output neurons of the cerebellar cortex, and their postsynaptic target neurons in the cerebellar nuclei, fire action potentials at high, sustained frequencies, suggesting spike rate modulation as a possible code. Yet, millisecond precise spatiotemporal spike activity patterns in Purkinje cells and inferior olivary neurons have also been observed. These results and ongoing studies suggest that the neuronal code used by cerebellar neurons may span a wide time scale from millisecond precision to slow rate modulations, likely depending on the behavioral context.

This talk is part of the Adrian Seminars in Neuroscience series.

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