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Emergence of HIV drug resistance during combinational therapy.

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We investigate the factors that determine the emergence of a drug-resistant HIV strain during the course of combination therapy. Using a within-host model for the dynamics of HIV , we study conditions under which mutant variants are selected in the presence of drug pressure and dominate the virus population. Local and global stability of resultant equilibrium points are discussed. An optimal combinational treatment regime that seeks to maximize the benefits of treatment while minimizing viral loads and side effects of the treatment regimen involved is explored. Preliminary results suggest that an optimal length of “drug holiday” can be found, which makes structured treatment plausible in the administration of ART .

This talk is part of the Worms and Bugs series.

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