Direct brain stimulation modulate physiology and behaviour in humans.

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• Rina Zelmann, PhD, Neurology at Massachusetts General Hospital & Harvard Medical School
• Tuesday 26 August 2025, 16:00-17:30
• Ground Floor Lecture Theatre, Department of Psychology.

If you have a question about this talk, please contact Adelaide Schiemer.

Direct brain electrical brain stimulation offers a causal window on human brain function and a route to therapy. This talk contrasts open-loop perturbation, single pulses and short trains used to map effective connectivity and state dependence across wake, sleep and anaesthesia, with closed-loop paradigms that detect neural features in intracranial EEG in real time to trigger stimulation. I’ll show how closed-loop experiments can adjust stimulation based on estimated cognitive state, producing rapid changes in cortical dynamics and measurable effects on behaviour during ongoing tasks. I’ll also discuss high-frequency oscillations and ripples as candidate biomarkers for targeting, and outline opportunities and limits for translating these methods to precision neuromodulation in humans.

The Host for this talk is Tristan Bekinschtein, tb419@cam.ac.uk.

This talk is part of the Zangwill Club series.

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