BSU Seminar: "Common atoms mixture models in some biostatistical inference problems"

Add to your list(s) Download to your calendar using vCal

• Prof Peter Mueller, University of Texas
• Tuesday 29 April 2025, 14:00-15:00
• Large Seminar Room, East Forvie Building, Forvie Site Robinson Way Cambridge CB2 0SR..

If you have a question about this talk, please contact Alison Quenault.

This will be a free hybrid seminar. To register to attend virtually, please click here: https://cam-ac-uk.zoom.us/meeting/register/4uUskN5ZQjaJzckpMbxQ1Q

We consider several examples of statistical inference for two or more related populations. In one example we characterize two patient populations that are relevant in the construction of a clinical study design, and propose a method to adjust for detected differences. Another example is about comparative immune profiling under two biologic conditions of interest when we identify shared versus condition-specific homogeneous cell subpopulations. In a third example we model spatially aligned cell subpopulations for spatial transcriptomics data.

Bayesian inference in all three applications requires prior probability models for two or more related distributions. We build on extensive literature on such models based on Dirichlet process priors. Related models are commonly known as dependent Dirichlet processes (DDP), with many variations and extensions beyond the Dirichlet process model.

One special feature in all three motivating applications is the focus on understanding the nature of the dependence across the related populations. In one application we aim to adjust for differences in population heterogeneity, in another we aim to identify and understand homogeneous subpopulations that are characteristic for one or the other condition.

This talk is part of the MRC Biostatistics Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• BHRU Annual Lecture 2015
• BHRU Annual Lecture 2016
• Biology
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge Immunology
• Cambridge talks
• Cardiovascular Epidemiology Unit Special Seminars
• Chris Davis' list
• Department of Public Health and Primary Care
• Graduate-Seminars
• Interested Talks
• Large Seminar Room, East Forvie Building, Forvie Site Robinson Way Cambridge CB2 0SR.
• Life Sciences
• Life Sciences
• ME Seminar
• MRC Biostatistics Unit Seminars
• Primary Care
• PublicHealth@Cambridge
• Trust & Technology Initiative - interesting events
• bld31
• my_list
• ndk22's list
• ob366-ai4er
• other talks
• primary care
• rp587

Note that ex-directory lists are not shown.