BSU Seminar: 'Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection'

Add to your list(s) Download to your calendar using vCal

• Mélanie Prague, Inria, University of Bordeaux
• Tuesday 23 May 2023, 14:00-15:00
• Online Seminar.

If you have a question about this talk, please contact Alison Quenault.

This will be a free online seminar. To register to attend, please click here: https://us02web.zoom.us/meeting/register/tZUuf-usqDovGdf1TbAtYgsGCRJmoz0Hmbfi

The definition of correlates of protection is critical for the development of next generation SARS -CoV-2 vaccine platforms. Here, we propose a model-based approach for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics and data mining of immunological markers. The application to three different studies in non-human primates evaluating SARS -CoV-2 vaccines based on CD40 -targeting, two-component spike nanoparticle and mRNA 1273 identifies and quantifies two main mechanisms that are a decrease of rate of cell infection and an increase in clearance of infected cells. Inhibition of RBD binding to ACE2 appears to be a robust mechanistic correlate of protection across the three vaccine platforms although not capturing the whole biological vaccine effect. The model shows that RBD /ACE2 binding inhibition represents a strong mechanism of protection which required significant reduction in blocking potency to effectively compromise the control of viral replication.

Based on elife paper https://doi.org/10.7554/eLife.75427

This talk is part of the MRC Biostatistics Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• BHRU Annual Lecture 2015
• BHRU Annual Lecture 2016
• Biology
• Cambridge Centre for Data-Driven Discovery (C2D3)
• Cambridge Immunology
• Cambridge talks
• Cardiovascular Epidemiology Unit Special Seminars
• Chris Davis' list
• Department of Public Health and Primary Care
• Graduate-Seminars
• Interested Talks
• Life Sciences
• Life Sciences
• ME Seminar
• MRC Biostatistics Unit Seminars
• Online Seminar
• Primary Care
• PublicHealth@Cambridge
• Trust & Technology Initiative - interesting events
• bld31
• my_list
• ndk22's list
• ob366-ai4er
• other talks
• primary care
• rp587

Note that ex-directory lists are not shown.