Physics of blastocyst morphogenesis

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• Dr. Jean-Léon Maître (Institut Curie, Paris) & Dr. Hervé Turlier (Collège de France, Paris)
• Wednesday 05 May 2021, 17:00-18:00
• Webinar.

If you have a question about this talk, please contact Dr. Adrien Hallou.

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The formation of the blastocyst during preimplantation development constitutes a unique opportunity to study living mammalian embryos. The blastocyst consists of a surface epithelium enveloping a fluid-filled lumen and a cluster of pluripotent stem cells. This specific architecture is key for the implantation and further the development of the mammalian embryo. Using biophysical measurements and modelling, we have uncovered over the past years some of the mechanisms shaping the blastocyst. We will discuss how changes in mechanical properties of cells drive the compaction of the embryo, differential positioning of cells within the embryo and the formation of the first mammalian lumen.

This talk is part of the Theory of Living Matter Group series.

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